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. 2022 May 4;12:798767. doi: 10.3389/fcimb.2022.798767

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Copyright © 2022 Osman, Garrec, de Souza, Zarubica, Belhaouari, Baudoin, Lepidi, Mege, Malissen, Scola and Devaux

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analysis of intestinal tissues from K18-hACE2 transgenic mice (virus free) and K18-hACE2 transgenic mice infected via intranasal administration of SARS-CoV-2. (A) Normal intestinal wall from control K18-hACE2 transgenic mouse (hematoxylin-phloxin-saffron staining). (B) Section of intestine from K18-hACE2 transgenic mouse infected with SARS-CoV-2. The upper, middle and lower panels correspond to samples from 3 different mice. Note the extensive necrosis and inflammation of the lamina propria of intestinal villi with degeneration of intestinal epithelial cells in the intestinal lumen.