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. 2022 May 16;10(5):e003819. doi: 10.1136/jitc-2021-003819

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Synergistic effect of CD73 specific inhibitor and ABZ therapy in the melanoma mouse model. (A) Mouse melanoma cell line B16F10 cells were injected into mice (n=6 mice per group) on day −6, ABZ (50 mg/kg) and APCP (400 µg/mouse) were administered alone or together as the chart indicated. (B) Tumor volume was measured on the indicated different time points (n=6 mice per group). Data represent mean±SD, *p<0.05, **p<0.01, ***p<0.001. (C) Photographs of representative tumors after ABZ and APCP treatment on day 12 in the B16F10 tumor burden mouse model. (D) Tumor weight was measured on day 12. Data represent mean±SD, ***p<0.001. (E) Mice weight was measured on the indicated different time points. (F) Representative profiles and quantification of flow cytometry-based detection of the PD-L1 from B16F10 tumor mass (n=6 mice per group). Data represent mean±SD, *p<0.05, **p<0.01, ***p<0.001. (G) Representative profiles and quantification of flow cytometry-based detection of the CD8⁺ in CD3⁺ TILs in B16F10 tumor mass from the different treatment groups (n=6 mice per group). Data represent mean±SD, *p<0.05, ***p<0.001. (H) Representative profiles and quantification of flow cytometry-based detection of the GZMB⁺ CD8⁺ in CD3⁺ TILs from the B16F10 tumor mass (n=6 mice per group). Data represent mean±SD, *p<0.05, **p<0.01, ***p<0.001. (I) Representative profiles and quantification of flow cytometry-based detection of the Foxp3⁺ in CD4⁺ TILs in B16F10 tumor mass from the different treatment groups (n=6 mice per group). Data represent mean±SD, *p<0.05, **p<0.01, ***p<0.001. ABZ, albendazole; APCP, adenosine 5'-(α,β-methylene) diphosphate; TILs, tumor infiltrates lymphocytes.