TABLE 1.
Clinical data and IgG(S) levels in the Main and Confirmatory cohorts in the two subgroups of NH residents with (COV‐Yes) or without (COV‐No) history of prior SARS‐CoV‐2 infection
| Main cohort | Confirmation cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| COV‐No | N | COV‐Yes | N | COV‐No | N | COV‐Yes | N | |
| Women (%) | 63% | 41 | 73% | 74 | 78% | 366 | 73% | 93 |
| Age (years) | 84 ± 9 | 41 | 84 ± 10 | 74 | 88 ± 8 | 366 | 87 ± 8 | 93 |
| BMI | 25.0 ± 7.0 | 40 | 25.6 ± 5.2 | 68 | — | — | ||
| GIR | 1.90 ± 0.63 | 40 | 1.90 ± 0.92 | 68 | — | — | ||
| Number of treatments | 6.93 ± 2.56 | 40 | 7.38 ± 3.49 | 68 | — | — | ||
| IgG(S) titers (BAU/ml) | ||||||||
| 1st IgG(S) median (IQR) | 621 (189–1741) | 41 | 2901*** a (1873–7805) | 74 | ||||
| 2nd IgG(S) median (IQR) | 92 (46–415) | 41 | 1555*** (776–2080) | 74 | 114 (38–322) | 366 | 1740*** (1095–2900) | 93 |
| 3rd IgG(S) median (IQR) | 3040 (1880–7970) | 35 | 4965(NS) (3070–9393) | 48 | 3795 (1748–7470) | 254 | 6675** (2503–14,550) | 52 |
| D Time (days) | ||||||||
| 1st IgG(S) b | 84 ± 22 | 41 | 101 ± 68 | 74 | ||||
| 2nd IgG(S) b | 210 ± 31 | 41 | 215 ± 38 | 74 | 212 ± 38 | 366 | 173 ± 41*** | 93 |
| 3rd IgG(S) c | 44 ± 8 | 35 | 42 ± 10 | 48 | 39 ± 10 | 254 | 42 ± 13 | 52 |
Note: IgG(S) (BAU/ml) represent median (IQR) values. BMI, body mass index, GIR, Group Iso Resources: Dependence score from 1 (completely dependent for most daily life activities) to 6 (completely independent) by using the AGGIR grid (Autonomy, Gerontology Group Iso Resources). Assessment of this score is mandatory for all NH residents in France (https://www.capretraite.fr/aide‐a‐domicile/perte‐dautonomie/grille‐aggir/).
Among the 74 COV‐Yes subjects, 50 had SARS‐Cov‐2 infection before the first vaccination and 20 a few days after the 2nd dose. After adjusting for the time since the last immunization, the 1st IgG(S) quantification showed similar levels in these 2 subgroups (median (IQR)): 3133 (1896–7497) vs. 2791 (1483–7592) respectively (p = 0.54).
Delta time between 2nd vaccination or COVID‐19 (if occurred after the 2nd vaccination) and the 1st or 2nd IgG (S) quantification.
Delta time between 3rd vaccination and 3nd IgG(S) quantification. **p < 0.01 and ***p < 0.001 versus COV‐No of the same cohort.