Table 2.

Descriptive characteristics of eligible studies included in this review in order of publication.

First author (ref). title, year country	Study design	Year of data collection and/or follow up period	n (% female)	Population description	ACE type/number	Age (years) mean (+ SD)	ACE – Identification method	AD – Identification method
Norton et al. (2011) Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: The Cache County Study, USA.	Longitudinal Cohort	1995–1997, 1998–2000, 2002–2004, 2005–2007	4,108 (57.4%)	Participants were recruited from The Cache County Study on Memory Health and Aging. A longitudinal, population-based study of (AD) and other dementias. The study was initiated in 1995, with the goal to examine genetic and environmental risk factors of AD and other dementias. Eligible participants were residents of Cache County, a rural area located in north eastern Utah.	1–Parental death	75.7 (±7.1)	The Utah Population Database of linked population-based information.	Clinical diagnosis according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria for Alzheimer's disease (NINCDS-ADRDA).
Norton et al. (2016) Family member deaths across adulthood predict Alzheimer's Disease risk. The Cache County Study, USA.	Longitudinal Cohort	1995–1997, 1998–2000, 2002–2004, 2005–2007	4,545 (56.7%)	As above.	1–Familial death	75.0 (±6.9)	As above.	As above.
Radford et al. (2017) Childhood Stress and Adversity is Associated with Late-Life Dementia in Aboriginal Australians, Australia.	Cross-sectional	March 2010 until September 2012	296 (61.8%)	Participants were Aboriginal and Torres Strait Is- lander Australians, from urban and rural communities who took part in the Koori Growing Old Well Study (KGOWS).	1–Childhood Aversity pooled result	66.1 (± 5.8)	The short form of the Childhood Trauma Questionnaire and the Koori Growing Old Well Study life course survey.	Clinical diagnosis based on the National Institute of Aging/Alzheimer's disease Association (NIA-AA) workgroup criteria.