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. 2022 May 16;10(5):e004113. doi: 10.1136/jitc-2021-004113

Figure 1.

Figure 1

SNORA38B was highly expressed in NSCLC and associated with poor prognosis. (A) Heatmap of differential gene expression in lung cancer tissues compared with adjacent normal tissues using TCGA database. Mapping by R software (V.4.0.2). (B) Six differentially expressed small nucleolar RNAs that associated with lung cancer stage and survival were screened out using Venn diagram. Mapping by R software. (C) Violin Plot of SNORA38B expression in tumor samples compared with adjacent normal samples using TCGA database. Mapping by R software. (D) Violin Plot of SNORA38B expression in different stages of NSCLC. Mapping by R software. (E–F) Representative images of SNORA38B expression in human lung/mouse tumor tissues and human/mouse lung tissues using RNAscope. Bar=50/100 µm. (G) Expression levels of SNORA38B in normal lung cell lines (16HBE, BEAS-2B, WI-38) and NSCLC cell lines (A549, 95D, SK-MES-1, H460, H520, H1299, H157, SPC-A-1, SK-LU-1 and H1975) were examined using qRT-PCR. (H) Kaplan-Meier survival analysis showed the correlation between SNORA38B expression and patient prognosis. Mapping by R software. Assays were conducted in triple. *p<0.05, **p<0.01, ***p<0.001, means±SD was shown. Statistical analysis was performed by Student’s t-test, Kruskal-Wallis, one-way analysis of variance and the log-rank test. NSCLC, non-small cell lung cancer; SNORNA, small nucleolar RNA; TCGA, The Cancer Genome Atlas.