Table 2.
Laboratory findings of the patients with multisystem inflammatory syndrome in children (MIS‐C) by age range
| Characteristic | All patients (n = 101) | 0–5 years (n = 29) | 5–12 years (n = 56) | >12 years (n = 16) | P |
|---|---|---|---|---|---|
| Haematology | |||||
| Total white blood cell count cells × 103/μL, median (IQR) | 8.3 (5.6–13.1) | 11.9 (7–18.1) | 7.9 (5.6–11.7) | 6.9 (3.9–9.9) | 0.018 |
| Neutrophil count cells × 103/μL, median (IQR) | 6.4 (3.8–10.4) | 8.39 (4.3–14) | 6.31 (4.2–10) | 5.77 (2.7–8.7) | 0.308 |
| Lymphocyte count cells/μL, median (IQR) | 1080 (715–1845) | 2000 (1380–5105) | 930 (707–1495) | 635 (510–995) | <0.001 |
| Platelet count cells × 103/μL, median (IQR) | 152 (103–257) | 267 (131–399) | 137 (100–180) | 162 (102–208) | 0.011 |
| Haemoglobin, g/dL, mean ± SD | 10.8 ± 1.5 | 10.6 ± 1.5 | 10.6 ± 1.3 | 11.9 ± 1.9 | 0.009 |
| Inflammatory markers | |||||
| CRP, mg/L, median (IQR) | 165 (112–228) | 129 (78.5–193) | 161 (128–228) | 203 (119–299) | 0.088 |
| ESR, mm/h, median (IQR) | 53 (30–84) [n = 84] | 51 (21–85) [n = 23] | 52 (27–87) [n = 49] | 55 (35–82) [n = 12] | 0.894 |
| Procalcitonin, μg/L, median (IQR) | 5 (0.58–20.2) [n = 89] | 3.72 (0.3–10.1) [n = 25] | 7 (0.9–24.5) [n = 49] | 2.39 (0.41–9.2) [n = 15] | 0.187 |
| Ferritin, μg/L, median (IQR) | 553 (272–1022) [n = 97] | 262 (141–646) [n = 27] | 630 (406–1084) [n = 54] | 545 (385–1032) [n = 16] | 0.054 |
| Biochemistry | |||||
| LDH, U/L, median (IQR) | 323 (264–404) | 325 (260–431) | 326 (268–394) | 310 (248–579) | 0.944 |
| Albumin, g/dL, median (IQR) | 3 (2.5–3.4) | 2.9 (2.4–3.6) | 3 (2.6–3.2) | 3.4 (2.5–3.9) | 0.158 |
| Sodium, mmol/L, median (IQR) | 133 (130–136) [n = 95] | 133 (131–136) [n = 27] | 132 (129–135) [n = 53] | 134 (131–139) [n = 15] | 0.308 |
| Urea, mg/dL, median (IQR) | 18.8 (12.7–28.5) | 15 (9–19.9) | 20 (14.7–27.7) | 29 (16.1–58.3) | 0.001 |
| Creatinine, mg/dL, median (IQR) | 0.48 (0.34–0.73) [n = 96] | 0.30 (0.25–0.47) [n = 26] | 0.49 (0.38–0.66) [n = 55] | 0.83 (0.7–1.24) [n = 15] | <0.001 |
| Triglyceride, mg/dL, median (IQR) | 230 (176–324) [n = 68] | 182 (113–320) [n = 18] | 269 (204–333) [n = 40] | 191 (103–239) [n = 10] | 0.006 |
| Cardiac markers | |||||
| Troponin, ng/L, median (IQR) | 13.3 (2.4–63) [n = 93] | 5.3 (1.8–16.2) [n = 26] | 19.8 (0.7–86.6) [n = 53] | 36.2 (4.37–519) [n = 14] | 0.035 |
| NT‐pro‐BNP, pg/mL, median (IQR) | 5656 (1577–12 503) [n = 44] | 1307 (400–8547) [n = 11] | 6773 (3180–14 151) [n = 25] | 4473 (206–8047) [n = 8] | 0.087 |
| Coagulation | |||||
| Fibrinogen, mg/dL, median (IQR) | 451 (350–628) [n = 92] | 423 (305–570) [n = 24] | 410 (341–612) [n = 52] | 577 (460–770) [n = 16] | 0.054 |
| D‐dimer, μg/L, median (IQR) | 2787 (1405–4500) [n = 99] | 2850 (1245–4727) [n = 28] | 2400 (1700–4850) [n = 55] | 2975 (1101–4245) [n = 16] | 1.000 |
CRP, C‐reactive protein; ESR, erythrocyte sedimentation rate; IQR, interquartile range; LDH, lactate dehydrogenase; NT‐pro‐BNP, N‐terminal pro‐B type natriuretic peptide; SD, standard deviation. Significant p values are indicated in bold.