Table 4.
The optimal cut‐off values, sensitivities, specificities, positive predictive value, and negative predictive value of laboratory findings were presented as indices predictive of the need for intensive care unit admission of patients with multisystem inflammatory syndrome in children (MIS‐C)†
| n | AUC | P | Cut‐Off | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| Procalcitonin levels, μg/L | 89 | 0.686 | 0.001 | >6 | 67.65 | 69.09 | 57.5 | 77.6 |
| INR | 99 | 0.681 | 0.003 | >1.25 | 55.26 | 85.25 | 70.0 | 75.4 |
| CRP, mg/L | 101 | 0.670 | 0.002 | >177 | 63.16 | 68.25 | 54.5 | 75.4 |
| Total protein, mg/dL | 82 | 0.659 | 0.009 | ≤5.9 | 77.78 | 54.35 | 57.1 | 75.8 |
| Creatinine levels, mg/dL | 96 | 0.654 | 0.011 | >0.5 | 65.79 | 72.41 | 61.0 | 76.4 |
| D‐dimer, μg/L | 99 | 0.651 | 0.007 | >2787 | 65.79 | 60.66 | 51.0 | 74.0 |
| Prothrombin time, s | 85 | 0.637 | 0.035 | >15.1 | 48.65 | 83.33 | 69.2 | 67.8 |
| Indirect bilirubin, mg/dL | 92 | 0.635 | 0.023 | >0.23 | 63.89 | 69.64 | 57.5 | 75.0 |
| Lymphocyte cells/μL | 101 | 0.633 | 0.021 | ≤930 | 63.16 | 66.67 | 53.3 | 75.0 |
| Platelet counts cells/μL | 101 | 0.628 | 0.026 | ≤173 000 | 78.95 | 49.21 | 48.4 | 79.5 |
†
Receiver operating characteristic analysis was used to determine the optimal cut‐off values of laboratory findings to predict the need for an intensive care unit.
AUC, area under an ROC curve; CRP, C‐reactive protein; INR,international normalized ratio; NPV, negative predictive value; PPV, positive predictive value.