TABLE 3.
Detection of mutations in cyp51A by AsperGenius® PCR (three most common mutations) and by cyp51A gene sequencing
| Isolate | AsperGenius® | cyp51A mutation | Azole compound MIC (µg/ml) | COVID‐19 |
|---|---|---|---|---|
| 2 | Negative | G54R | ITC and POS >8 | No |
| 3 | Negative | F46Y, M172V, E427K | ITC = 1.5 | Yes |
| 8 | Negative | Negative | POS = 0.25 | Yes |
| 9 | Negative | Negative | POS = 0.25 and VRZ = 2 | No |
| 10 | Negative | Negative | POS = 0.25 and VRZ = 2 | Yes |
| 14 | Tr34/l98h | L98H | VRZ = 8, ITC >8, POS = 1 and ISC = 4 | Yes |
| 17 | Negative | Negative | VRZ = 2 and ISC = 2 | Yes |
| 26 | Negative | Negative | POS = 0.25 | Yes |
| 29 | Negative | Negative | POS = 2 and ISC = 2 | Yes |
| 30 | Negative | Negative | POS = 0.5, VRZ = 4 and ISC = 2 | Yes |
Abbreviations: ISC, isavuconazole; ITC, itraconazole; POS, posaconazole; VRZ, voriconazole.