Figure 5.

High TRIP13 expression induces NDP resistance via decreasing PARP and γH2A.X expression in ESCC. (a) The cleaved PARP expression level of the TRIP13 knockdown group increased with the effect of nedaplatin in TE1 cells examined by Western blot. Also, the γH2A.X expression level increased after the effect of nedaplatin examined by Western blot. (b) The γH2A.X expression level of the TRIP13 overexpression group was lower in KYSE150 cells tested by Western blot. (c) The cleaved PARP expression level of the TRIP13 overexpression group decreased with the effect of nedaplatin in KYSE510 cells examined by Western blot. Also, the γH2A.X expression level decreased after the effect of nedaplatin examined by Western blot.