Figure 6.

Low TRIP13 expression inhibits NDP resistance via increasing apoptotic cells, increasing the expression of proapoptotic protein and decreasing the expression of antiapoptotic protein in ESCC. (a, b) The proportion of apoptotic cells increased in TE1 cells treated with TRIP13 knockdown and NDP for 48 h tested by flow cytometry. (c) The apoptosis promotion degree was enhanced in TRIP13 knockdown TE1 cells with DNP treatment. (d) The expression of cleaved caspase-3 and Bax increased, and the expression of Bcl-2 decreased in TE1 cells with TRIP13 knockdown and NDP intervention tested by Western blot.