Figure 7.

High TRIP13 expression induces NDP resistance via decreasing apoptotic cells, decreasing the expression of proapoptotic protein and increasing the expression of anti-apoptotic protein in ESCC. (a, b, e, f) The proportion of apoptotic cells decreased in KYSE150 and KYSE510 cells treated with TRIP13 overexpression and NDP for 48 h tested by flow cytometry. (c, g) The apoptosis inhibition degree was reduced in TRIP13 overexpression KSYE150 and KYSE510 cells with DNP treatment. (d, h) The expression of cleaved caspase-3 and Bax decreased, and the expression of Bcl-2 increased in KYSE150 and KYSE510 cells with TRIP13 overexpression and NDP intervention tested by Western blot.