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. 2021 Dec 11;7(2):e10277. doi: 10.1002/btm2.10277

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© 2021 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Tolerance of tPA‐FSNs in healthy mice. (a) After receiving 0, 50, 100, or 200 mg/kg tissue‐type plasminogen activator‐FSN (tPA‐FSN), healthy mice were weighed daily for 5 days and animal weight was normalized to their starting weight. (b) Food consumption was monitored via a change in food weight of the cage divided by the number of animals in the cage and measured for 5 days after tPA‐FSN injection. n = 5 animals/group. Mean ± SD is shown. Data were analyzed via a two‐way analysis of variance with a Tukey's post hoc test using a 95% confidence interval