FIGURE 1.

Two‐phase approach to extract early predictive critical process parameters (CPPs) and critical quality attributes (CQAs) for CD4⁺/CD8⁺ T_N + T_CM cells. (a) Design‐of‐experiment (DOE) modeling and optimization of process parameters. (b) Experimental region studied and optimized for total live CD4⁺ T_N + T_CM cells. (c) Total live CD4⁺ T_N + T_CM cells across the overall study design (two experiments varying process parameters). (d) Integrative multiomics approach through (e) a machine learning consensus analysis to identify early predictive CPPs and CQAs putative candidates for both total live CD4⁺ and CD8⁺ T_N + T_CM cells