FIGURE 2.

OECs‐Exo reversed pro‐inflammatory markers in microglia induced by LPS treatment. (a) Schematic diagram showing adding OECs‐Exo into microglia pretreated with LPS. OECs‐Exo could reverse the induced mRNA expression of pro‐inflammatory markers of iNOS (b), CD86 (c), IL‐12 (d), and IL‐18 (e) in microglia upon LPS treatment in a concentration‐dependent manner. OECs‐Exo could increase the mRNA levels of anti‐inflammatory markers of IL‐4 (f) and Arg1 (g), except for no significant change of CD206 (h). Results are presented as mean ± SEM. N = 3, *p < 0.05, **p < 0.01, ***p < 0.001