Table 2.

Characteristic features of major non-infectious granulomatous disease.

Diagnosis	Key features
Sarcoidosis	Prominent well formed, discrete, non-necrotizing granulomas in lymphangitic pattern
Berylliosis	Well-formed, compact, non-necrotizing “sarcoid-like” granulomas within the interstitium correlation with the exposure history and demonstrating a beryllium-specific immune response with beryllium lymphocyte proliferation testing, or tissue analysis may be helpful in establishing the diagnosis
Hypersensitivity pneumonitis	Scattered small, poorly formed granulomas or multinucleated giant cells in interstitium in a background of prominent chronic interstitial inflammation
Aspiration pneumonia	Aspirated material surrounded by foreign-body type granulomas or multinucleated giant cells
Granulomatosis with polyangiitis (GPA)	Suppurative granulomas with dirty necrosis and necrotizing vasculitis
Eosinophilic granulomatosis with polyangiitis (EGPA)	Necrotizing granulomas, necrotizing vasculitis, and prominent eosinophils
Rheumatoid nodule	Multiple subpleural necrobiotic nodules identical to subcutaneous nodules; most patients also have subcutaneous nodules and high rheumatoid titers.