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. Author manuscript; available in PMC: 2022 May 18.
Published in final edited form as: Bioorg Med Chem. 2020 Aug 6;28(20):115698. doi: 10.1016/j.bmc.2020.115698

Scheme 3.

Scheme 3.

Synthesis of compounds 18 and 19. aReagents and conditions: (a) CuI, K2CO3, HO(CH2)2OH, i-PrOH, 80 °C, 40%; (b) triethylamine, phenylacetyl chloride, DCM, rt, 66%.