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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Thorax. 2021 Apr 21;77(1):47–57. doi: 10.1136/thoraxjnl-2020-216469

Figure 1.

Figure 1

Elevated sphingosine kinase 1 (SPHK1) and lysyl oxidase (LOX) expression are noted in lung tissue of neonates with severe BPD. Paraffin-embedded lung sections were used to assess expression of SPHK1 (A) and LOX by immunohistochemistry (C) in the lung tissue of neonates with BPD compared with controls. Intensity of antibody staining (brown) was quantified in halo system using scanned lung images (B and D). LOX was also elevated in the tracheal aspirates of newborns with severe BPD (E). Qquantified data show significance (F). Correlation test showed significant relationship (r=0.831) between LOX content in TA detected by immunoblot and the S1P level estimated (G). Original view, 10×, scale bar 100 μm. Statistical analyses done with Pearson correlation and Mann-Whitney U test. Details of patients are given in online supplemental tables 12. BPD, bronchopulmonary dysplasia; S1P, sphingosine-1-phosphate.