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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2022 Mar 31;29(4):357–368. doi: 10.1038/s41594-022-00750-6

Extended Data Fig. 5. Close-up view of asymmetric IR/insulin LeuA13R complex.

Extended Data Fig. 5

a. Overall view of asymmetric IR/insulin LeuA13R complex in two orthogonal views.

b. The close-up view of the contact of site-1 bound insulin LeuA13R at FnIII-1 domain in the asymmetric IR/insulin LeuA13R complex. The location of this interaction in the asymmetric dimer is indicated by a blue box in a.

c. The close-up view of the binding of a dimeric insulin at asymmetric IR/insulin LeuA13R complex. The location of this interaction in the asymmetric dimer is indicated by a red box in a.