Table 1.
List of studies enrolled in simulation process.
| Trial acronym | Full name | Regions | Sample size | Follow-up years | Reference no. |
|---|---|---|---|---|---|
|
| |||||
| LEADER | The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results Trial | EU, US, Asia, Others | 9340 | 3.8 | 21 |
| CANVAS | The Canagliflozin Cardiovascular Assessment Study | EU, US, Others | 10 142 | 4 | 22 |
| EMPA-REG OUTCOME | The Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients–Removing Excess Glucose Study | EU, US, Asia, Others | 7020 | 3.1 | 23 |
| TIMI-53 | The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)–Thrombolysis in Myocardial Infarction 53 trial | EU, US, Asia, Others | 16 492 | 2.1 | 24 |
| ADDITION-Europe | Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care | EU | 3057 | 5.3 | 25 |
| ELIXA | The Evaluation of Lixisenatide in Acute Coronary Syndrome Trial | EU, US, Asia, Others | 6068 | 2.1 | 26 |
| PROactive | Prospective Pioglitazone Clinical Trial in Macrovascular Events | EU | 5238 | 2.9 | 27 |
| ROADMAP | Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study | EU | 4447 | 3.2 | 28 |
| CARDS | Collaborative Atorvastatin Diabetes Study | EU | 2838 | 3.9 | 29 |
| Advance | The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation Trial | EU, US, Asia, Others | 11 140 | 5 | 30 |
| RECORD | Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes | EU | 4447 | 5.5 | 31 |
| ASPEN | The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Mellitus | EU, US, Asia, Others | 2410 | 4 | 32 |
| DIABHYCAR | Non-insulin-dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril Study | EU, Others | 4912 | 4 | 33 |
| TECOs | Trial Evaluating Cardiovascular Outcomes with Sitagliptin | EU, US, Asia, Others | 14 671 | 3 | 34 |
| FIELD | Fenofibrate Intervention and Event Lowering in Diabetes Study | EU, Others | 9795 | 5 | 35 |
| VADT | Veterans Affairs Diabetes Trial | US | 1791 | 5.6 | 36 |
| ORIGIN | The Outcome Reduction with an Initial Glargine Intervention Trial | EU, US, Others | 12 537 | 6.2 | 37 |
| ACCORD | The Action to Control Cardiovascular Risk in Diabetes Trial | US | 10 251 | 3.5 | 38 |