. Author manuscript; available in PMC: 2022 May 18.

Published in final edited form as: Oncogene. 2018 May 10;37(33):4489–4504. doi: 10.1038/s41388-018-0251-y

Table 1.

Inverse expression of Notch-1 and PTEN in breast cancer patient tumors is associated with poorer outcome

A. Co-Expression correlations of Notch-1 and PTEN
	Rank correlation	p-value
Curtis	−0.139	0.051
Bonnefoi	−0.1537	0.052
Hatzis	−0.03651	0.412
B. Cox Proportional Hazards Model (all BC)
	Hazard Function Estimate	p-value
Notch-1 Coefficient	0.112	0.0636
PTEN Coefficient	−0.227	0.0038
C. Cox Proportional	Hazards Model (HER2+)
	Hazard Function Estimate	p-value
Notch-1 Coefficient	0.107	0.2344
PTEN Coefficient	−0.292	0.0133
HER2 Coefficient	0.540	8.85 × 10⁻⁵

A Correlation of Notch-1 and PTEN co-expression in each of the three breast microarray data sets as calculated by Spearman’s correlation coefficient

B Co-expression of high Notch-1 and low PTEN regardless of HER2 status (all BC) correlates with an overall decrease in patient survival time in the Curtis Breast dataset as determined by the Cox proportional hazards model. The log-rank test p-value = 0.001262

C In the HER2+ dataset, the overall significance of Notch-1, PTEN, and HER2 is 3.11 × 10⁻⁵ by the Log rank test. The overall significance of Notch-1 and PTEN based on HER2+ status is 0.022, by the likelihood ratio test