Table 5:
Comparison of rate of change of T2 parameters for each weight loss method group compared to the stable weight group over 96 months
| Stable weight | Diet& Exercise | P-value | Diet | P-value | Exercise | P-value | |
|---|---|---|---|---|---|---|---|
| N=380 | N=101 | N=41 | N=33 | ||||
| T2 Parameters | Change in T2 ms/year 95% CI | Diet& Exercise vs. SW | Change in T2 ms/year 95% CI | Diet vs. SW | Change in T2 ms/year 95% CI | Exercise vs. SW | |
|
| |||||||
| Cartilage T2 | |||||||
| Global knee | 0.37 [0.26, 0.47] | 0.14 [0.09, 0.18] | 0.003 | 0.15 [0.03, 0.46] | 0.04 | 0.40 [0.24, 0.55] | 0.85 |
| PAT | 0.30 [0.21, 0.38] | 0.26 [0.02, 0.53] | 0.81 | 0.24 [0.18, 0.56] | 0.40 | 0.44 [0.03, 0.86] | 0.31 |
| MT | 0.55 [0.41, 0.69] | 0.06 [0.02, 0.32] | <0.001 | 0.07 [0.02, 0.36] | <0.001 | 0.42 [0.31, 0.75] | 0.13 |
| LT | 0.42 [0.29, 0.55] | 0.34 [0.11, 0.57] | 0.65 | 0.22 [−0.10, 0.53] | 0.44 | 0.52 [0.18, 0.86] | 0.12 |
| MF | 0.23 [0.17, 0.38] | 0.04 [0.02, 0.21] | 0.02 | 0.27 [0.05, 0.50] | 0.53 | 0.29 [0.07, 0.52] | 0.73 |
| LF | 0.53 [0.38, 0.69] | 0.25 [0.21, 0.41] | 0.02 | 0.51 [0.28, 0.73] | 0.14 | 0.53 [0.30, 0.76] | 0.78 |
| Deep layer T2 | |||||||
| Global knee | 0.40 [0.28, 0.52] | 0.08 [0.04, 0.12] | <0.001 | 0.09 [0.00, 0.18] | 0.001 | 0.34 [0.16, 0.53] | 0.21 |
| PAT | 0.20 [0.12, 0.28] | 0.13 [0.09, 0.39] | 0.38 | 0.09 [0.02, 0.42] | 0.22 | 0.24 [0.17, 0.64] | 0.85 |
| MT | 0.49 [0.34, 0.64] | 0.09 [0.02, 0.39] | <0.001 | 0.12 [0.05, 0.36] | <0.001 | 0.21 [0.07, 0.34] | 0.01 |
| LT | 0.38 [0.25, 0.51] | 0.33 [0.13, 0.52] | 0.13 | 0.06 [0.03, 0.28] | 0.01 | 0.33 [0.11, 0.55] | 0.34 |
| MF | 0.37 [0.18, 0.56] | 0.03 [0.01, 0.6] | 0.001 | 0.28 [0.01, 0.57] | 0.06 | 0.30 [0.02, 0.59] | 0.44 |
| LF | 0.63 [0.47, 0.80] | 0.16 [0.08, 0.31] | <0.001 | 0.13 [0.01, 0.34] | 0.002 | 0.55 [0.28, 0.80] | 0.18 |
| Superficial layer T2 | |||||||
| Global knee | 0.36 [0.29, 0.43] | 0.34 [0.13, 0.58] | 0.87 | 0.41 [0.10, 0.73] | 0.53 | 0.67 [0.38, 1.02] | 0.013 |
| PAT | 0.46 [0.35, 0.56] | 0.28 [0.04, 0.56] | 0.20 | 0.40 [0.08, 0.56] | 0.79 | 0.26 [0.04, 0.40] | 0.026 |
| MT | 0.61 [0.41, 0.80] | 0.13 [0.08, 0.25] | 0.001 | 0.17 [0.01, 0.72] | 0.02 | 0.63 [0.43, 0.92] | 0.96 |
| LT | 0.51 [0.41, 0.61] | 0.56 [0.24, 0.88] | 0.59 | 0.42 [0.02, 0.85] | 0.59 | 0.77 [0.31, 1.24] | 0.14 |
| MF | 0.18 [0.06, 0.63] | 0.09 [0.18, 0.37] | 0.27 | 0.12 [0.01, 0.41] | 0.07 | 0.33 [0.12, 1.50] | 0.023 |
| LF | 0.42 [0.34, 0.51] | 0.49 [0.21, 0.78] | 0.32 | 0.61 [0.22, 1.00] | 0.15 | 0.69 [0.27, 1.11] | 0.08 |
LF, lateral femur; LT, lateral tibia; MF, medial femur; MT, medial tibia; PAT, patella
*
The associations between different weight loss methods and rate of change in cartilage T2 over 96 months were assessed using multivariable regression models adjusting for age, sex, baseline BMI and baseline KL score. Significant results (P < 0.05) are bolded.