Table 9. RNA Therapies for Respiratory Diseases.
| respiratory disease | drug name/lab code | type of RNA | target | company | development stage | clinical trial number |
|---|---|---|---|---|---|---|
| acute respiratory distress syndrome | Descartes-30 | mRNA | neutrophil extracellular traps | Cartesian Therapeutics | phase I/II | NCT04524962229 |
| cystic fibrosis | MRT5005 | mRNA | cystic fibrosis transmembrane conductance regulator | Translate Bio | phase I/II | NCT03375047236 |
| cystic fibrosis | ARO-ENaC | siRNA | epithelial sodium channel α subunit | Arrowhead Pharmaceuticals | phase I/IIa | NCT04375514237 |