Table 6.

Association between confounders and time to weaning from invasive mechanical ventilation (cox-type model for calorie intake)

	Variable name	HR	LL CI 95%	UL CI 95%	p value
Predictor variables	Age	1.00	0.99	1.00	0.245
	Female vs. male	1.23	0.98	1.55	0.079
	Body weight (kg)	1.00	0.99	1.00	0.189
	Surgical versus non-surgical ICU admission	1.45	1.12	1.90	0.006
	Main reason for ICU admission: Infection (yes vs. no)	1.25	0.99	1.59	0.066
	Main reason for ICU admission: Respiratory (yes vs. no)	0.59	0.46	0.75	< 0.001
	Number of severe comorbidities	1.13	1.00	1.28	0.046
	APACHE II	1.00	0.99	1.01	0.847
	Average SOFA score of preceding days (d1–d5)	0.89	0.85	0.92	< 0.001
	Sum of preceding days with HAIs (d1–d5)	0.90	0.83	0.97	0.006
	Baseline functional status	0.97	0.91	1.03	0.316
	% of total calories given via the enteral and oral route (d1–d5)	1.00	1.00	1.01	0.075
Random effect	Study site				< 0.001

A HR < 1 indicates a longer time until extubation

APACHE Acute Physiology and Chronic Health Evaluation, ICU intensive care unit, HR hazard ratio, LL lower limit, UL upper Limit, CI confidence interval, HAI hospital acquired infection