Table 1.
Demographics, severity scores and laboratory results at ICU admission in all the patients and in patients with or without cytomegalovirus (CMV) blood reactivation
| All patients (n = 431) |
No CMV reactivation (n = 343) |
CMV reactivation (n = 88) |
p value | |
|---|---|---|---|---|
| Age (years; median, IQR) | 65 (56–72) | 63 (54–72) | 69 (64–75) | < 0.001 |
| Sex, male (n, %) | 323 (74.9) | 248 (72,3) | 75 (85.2) | 0.013 |
| Hypertension (n, %) | 222 (51.7) | 174 (50.9) | 48 (55.7) | 0.408 |
| Diabetes (n, %) | 96 (22.4) | 71 (20.8) | 25 (28.4) | 0.128 |
| Immunosuppressiona (n, %) | 68 (15.9) | 47 (13.7) | 21 (23.9) | 0.021 |
| BMI (kg/m2; median, IQR) | 29 (26–33) | 29 (26–33) | 29 (26–33) | 0.738 |
| SAPSII (median, IQR) | 35 (30–40) | 34 (28–39) | 37 (34–44) | < 0.001 |
| D-dimer (ng/ml; median, IQR) | 1470 (820–2840) | 1400 (820–2660) | 1805 (855–4760) | 0.166 |
| LDH (U/L; median, IQR) | 808 (632–1086) | 786 (633–1081) | 874 (623–1148) | 0.260 |
| Lymphocyte count (109/L; median, IQR) | 0.65 (0.46–0.91) | 0.66 (0.47–0.90) | 0.61 (0.41–0.96) | 0.307 |
| Platelet count (109/L; median, IQR) | 219 (169–286) | 227 (182–291) | 186 (140–247) | < 0.001 |
| C-reactive protein (mg/dl; median, IQR) | 7.2 (2.1–17.6) | 7.5 (2.6–17.5) | 6.2 (1.2–18.4) | 0.408 |
| Procalcitonin (ng/ml; median, IQR) | 0.20 (0.10–0.60) | 0.2 (0.1–0.5) | 0.3 (0.11–1.15) | 0.019 |
| PaO2/FiO2 (mmHg; median, IQR) | 104 (83–138) | 104 (84–140) | 106 (83–135) | 0.870 |
BMI body mass index; SOFA simplified organ failure assessment; SAPSII Simplified Acute Physiology Score II; LDH lactate dehydrogenase
aIncluding active hematological malignancies, neoplastic diseases, AIDS, transplants