Table 3.
Unadjusted and adjusted analysis for mortality censored at day 60
| Survived (n = 288) |
Not survived (n = 143) |
Unadjusted HR (95% CI) p value |
Adjusted HR (95% CI) p value |
|
|---|---|---|---|---|
| Age (years; median, IQR) | 63 (53–71) | 69 (62–75) | 1.043 (1.025–1.061); p < 0.001 | 1.01 (0.989–1.031); p = 0.359 |
| SAPSII (median, IQR) | 33 (28–38) | 37 (34–44) | 1.042 (1.029–1.055); p < 0.001 | 1.022 (1.004–1.041); p = 0.017 |
| LDH (U/L; median, IQR) | 773 (620–1050) | 909 (671–1245) | 1.001 (1–1.001); p < 0.001 | 1 (1–1.001); p = 0.212 |
| platelet count (109/L; median, IQR) | 233 (188–297) | 188 (139–248) | 0.994 (0.992–0.996); p < 0.001 | 0.996 (0.994–0.998); p = 0.001 |
| PaO2/FiO2 (mmHg; median, IQR) | 109 (86–143) | 99 (81–129) | 0.994 (0.990–0.999); p = 0.01 | 0.998 (0.994–1.002) p = 0.354 |
| Invasive mechanical ventilation (n, %) | 140 (48.6) | 136 (95.1) | 14.904 (6.56–33.84); p < 0.001 | 9.02 (3.58–22.87); p < 0.001 |
| New bacterial infection (n, %) | 58 (20.1) | 99 (69.2) | 4.638 (3.174–6.777); p < 0.001 | 2.571 (1.665–3.972); p < 0.001 |
| Probable Invasive Pulmonary Aspergillosis (n, %) | 38 (13.2) | 36 (25.2) | 2.041 (1.389–3.001); p < 0.001 | 1.023 (0.675–1.54); p = 0.916 |
| CMV reactivation (n, %) | 29 (10.1) | 59 (41.3) | 2.53 (1.771–3.613); p < 0.001 | 1.141 (0.757–1.721); p = 0.528 |
Only factors with p < 0.1 at unadjusted analysis are reported
SAPSII Simplified Acute Physiology Score II: LDH lactate dehydrogenase; CMV cytomegalovirus