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. Author manuscript; available in PMC: 2022 May 18.
Published in final edited form as: Biochem Pharmacol. 2020 Oct 17;183:114291. doi: 10.1016/j.bcp.2020.114291

Fig. 3.

Fig. 3.

Antinocicpetive effects of PnCs1, PnCS1[W4K], PnCS1[R6E] and PnCS1 [W7Y] in a mouse model of NaV1.7 mediated nociception. Local intraplantar injection of 10 μM PnCs1 and PnCs1[R6E] partially reduced OD1 induced pain behaviours (n = 5 per group) while intraplantar injection of 100 μM of all four peptides reduced pain behaviours (n = 5 per group). Vehicle administration did not cause significant pain (1.3 ± 0.5% of OD1 control). Data are expressed as mean ± SD. Statistical significance was determined using one-way ANOVA with Dunnett’s post-test; *, p < 0.05; **, p < 0.01, ***, p < 0.001 compared to OD1 control.