Table 3.
Hill coefficients for the concentration-response curves constructed to obtain the IC50 values in table 2.
| Peptide | NaV1.2 | NaV1.4 | NaV1.5 | NaV1.6 | NaV1.8 |
|---|---|---|---|---|---|
|
| |||||
| PnCS1 | 0.9 ± 0.2 | 1.2 ± 0.1 | 0.9 ± 0.4 | 0.9 ± 0.3 | / |
| PnCS1[R2A] | 0.9 ± 0.2 | 1.1 ± 0.2 | 0.7 ± 0.2 | 0.9 ± 0.4 | / |
| PnCS1[R3A] | 1.0 ± 0.2 | 0.8 ± 0.2 | / | 1.1 ± 0.3 | / |
| PnCS1[W4A] | 0.8 ± 0.2 | 0.9 ± 0.3 | 0.6 ± 0.2 | 0.8 ± 0.2 | / |
| PnCS1[R6A] | 0.5 ± 0.3 | 0.9 ± 0.2 | 0.9 ± 0.4 | 1.0 ± 0.2 | / |
| PnCS1[W7A] | 0.6 ± 0.2 | 0.7 ± 0.1 | 0.7 ± 0.2 | 0.9 ± 0.2 | / |
| PnCS1[N8A] | 1.0 ± 0.1 | 0.9 ± 0.4 | 1.0 ± 0.1 | 1.1 ± 0.2 | / |
| PnCS1[R9A] | 0.8 ± 0.4 | 1.0 ± 0.2 | 0.7 ± 0.2 | 1.2 ± 0.3 | / |
| PnCS1[R2K] | 1.3 ± 0.4 | 1.2 ± 0.1 | 0.6 ± 0.3 | 0.8 ± 0.3 | / |
| PnCS1[R3K] | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.3 | 1.2 ± 0.3 | / |
| PnCS1[W4K] | 0.6 ± 0.3 | 0.9 ± 0.2 | 1.0 ± 0.1 | 1.0 ± 0.2 | / |
| PnCS1[A5K] | 1.1 ± 0.1 | 0.8 ± 0.3 | 0.7 ± 0.3 | 0.6 ± 0.2 | / |
| PnCS1[R6K] | 0.7 ± 0.2 | 0.7 ± 0.2 | 1.1 ± 0.3 | 1.1 ± 0.1 | / |
| PnCS1[W7K] | 0.8 ± 0.1 | 0.9 ± 0.3 | 1.1 ± 0.2 | 0.7 ± 0.2 | / |
| PnCS1[N8K] | 0.7 ± 0.2 | 0.8 ± 0.2 | 0.7 ± 0.4 | 0.8 ± 0.4 | / |
| PnCS1[R9K] | 0.6 ± 0.2 | 0.7 ± 0.1 | 0.8 ± 0.3 | 0.9 ± 0.3 | / |
| PnCS1[R2E] | / | / | / | / | / |
| PnCS1[R3E] | / | / | / | / | / |
| PnCS1[W4E] | 0.9 ± 0.3 | 1.3 ± 0.4 | / | 1.4 ± 0.3 | / |
| PnCS1[A5E] | 1.2 ± 0.2 | / | 0.7 ± 0.2 | 1.8 ± 0.5 | / |
| PnCS1[R6E] | / | / | / | / | / |
| PnCS1[W7E] | / | / | / | / | / |
| PnCS1[N8E] | / | / | / | / | / |
| PnCS1[R9E] | / | / | / | / | / |
| PnCS1[W4Y] | / | / | / | / | / |
| PnCS1[W7Y] | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.3 | 0.6 ± 0.2 | / |
| PnCS1AcAm | / | / | / | / | / |
| PnCS1DeAm | / | / | / | / | / |
| PnCS1Ac | / | / | / | / | / |