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IC50 values of PnCS1, PnCS1[W4K], PnCS1[R6E] and PnCS1[W7Y] on NaV subtypes involved in pain.
| IC50 (μM) | PnCS1 | PnCS1[W4K] | PnCS1[R6E] | PnCS1[W7Y] |
|---|---|---|---|---|
|
| ||||
| NaV1.1 | 0.8 ± 0.3 a | 0.4 ± 0.2 | >100 | 2.2 ± 0.4 |
| NaV1.3 | 1.1 ± 0.4 | 1.3 ± 0.4 | >100 | 4.1 ± 0.8 |
| NaV1.6 | 0.7 ± 0.3 | 0.7 ± 0.4 | >100 | 0.7 ± 0.3 |
| NaV1.7 | 0.9 ± 0.2 | 7.4 ± 0.5 | > 100 | 8.2 ± 0.3 |
IC50 values for n > 5, ±SD.
