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IL-17 signaling pathways. IL-17A/A homodimer, IL-17F/F homodimer and IL-17A/F heterodimer can each stimulate IL-17RA and IL-17RC receptor complexes on the surface of target cells like epithelial cells, endothelial cells and fibroblasts. The SEFIR motif recruits Act1 leading to the induction of downstream NF-kB and MAPK pathways. Pro-inflammatory cytokines like IL-1, IFN-γ, and IL-8 are then induced.
