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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Nature. 2021 Dec 22;601(7893):428–433. doi: 10.1038/s41586-021-04244-1

Extended Data Fig. 6 |. Dietary valine restriction does not affect LSK and thymocytes.

Extended Data Fig. 6 |

a, Frequency of LSK and different progenitors (GMP, CMP and MEP) from mice fed either a complete valine proficient diet (8g/Kg valine), valine deficient diet (0g/Kg valine) or valine deficient (0g/Kg valine) diet substituted with 0.8g/l valine in drinking water (right) (mean ± SD of n=4 animals each condition; two-sided unpaired t-test). b, Representative flow cytometry plots of the different hematopoietic compartments highlighted in (a). c, Frequency of intra-thymic T-cell population represented as percentage of CD45+ cells from mice fed either a valine proficient diet (8g/Kg valine), valine deficient diet (0g/Kg valine) or valine deficient diet (0g/Kg valine) substituted with 0.8g/l valine in drinking water for 4 weeks (mean ± SD of n=4 animals each condition; Two-way Anova analysis with Tukey multiple test correction). d, Representative flow cytometry plots of the different thymocyte subsets from (c).