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. 2022 Apr 2;23(3):bbac092. doi: 10.1093/bib/bbac092

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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BiTSC reconstructs tumor phylogeny of metastatic colorectal cancer. (A) The phylogeny tree of metastatic colorectal cancer reconstructed by BiTSC. (B) The subclone assignment. (C) The number of overlapped cells contained in subclones identified by BiTSC and cells contained in the targeted region, where PD stands for Primary Diploid, PA stands for Primary Aneuploid, MD stands for Metastatic Diploid, and MA stands for Metastatic Aneuploid in [33]. (D) The CNA subclonal genotype matrix estimated by BiTSC, where LINGO2: 1–5 represent different loci in the genomic region of LINGO2 on the chromosome, as well as SPEN:1-2 and APC:1-2. (E) The SNV subclonal genotype matrix estimated by BiTSC.

Inline graphic — BiTSC reconstructs tumor phylogeny of metastatic colorectal cancer. (A) The phylogeny tree of metastatic colorectal cancer reconstructed by BiTSC. (B) The subclone assignment. (C) The number of overlapped cells contained in subclones identified by BiTSC and cells contained in the targeted region, where PD stands for Primary Diploid, PA stands for Primary Aneuploid, MD stands for Metastatic Diploid, and MA stands for Metastatic Aneuploid in [33]. (D) The CNA subclonal genotype matrix estimated by BiTSC, where LINGO2: 1–5 represent different loci in the genomic region of LINGO2 on the chromosome, as well as SPEN:1-2 and APC:1-2. (E) The SNV subclonal genotype matrix estimated by BiTSC.