TABLE 2.
Mutations in FKS for isolates of C. albicans, C. glabrata, P. kudriavzevii, C. tropicalis, and K. marxianus having caspofungin MIC ≥ 0.5 mg/L or resistant to anidulafungin according to the EUCAST BP
| Range of MICs (mg/L) |
|||||||
|---|---|---|---|---|---|---|---|
| Species (nbr of isolates sequenced) | Nbr of isolates non-WT | Mutation | Localization | Caspo | Mica | Anidula | Mutations described |
| Candida albicans (n = 20) | 1 | F641S | HS1 | 1 | 0.25 | 0.25 | 37 |
| 9 | S645P | HS1 | 4–>4 | 0.5 –>4 | 0.25–1 | 36 | |
| 8 | S645S/P | HS1 | 0.5–2 | 0.25–1 | 0.015–1 | 36 | |
| 1 | R647G | HS1 | 0.5 | 0.5 | 0.03 | 16 | |
| 1 | R1361G | HS2 | 0.5 | 0.25 | 0.25 | 16 | |
| Candida glabrata (n = 27) | 1 | F625S | FKS1HS1 | >4 | 0.5 | 2 | 11 |
| 4 | DelF659 | FKS2HS1 | 4–>4 | 0.25–2 | 1–2 | 11 | |
| 1 | F659S | FKS2HS1 | 0.5 | 0.06 | 0.5 | 43 | |
| 1 | F659V | FKS2HS1 | 4 | 0.06 | 1 | 39 | |
| 7 | S663P | FKS2HS1 | 1–>4 | 0.125–2 | 0.25–4 | 11 | |
| 1 | S663F | FKS2HS1 | 1 | 0.25 | 1 | 43 | |
| 1 | F659S +L664V | FKS2HS1 | 0.5 | 0.06 | 1 | 16 | |
| 1 | S663P +M1439R | FKS2HS1 + FKS2 non-hotspot alteration | 4 | 0.5 | 1 | This study | |
| 3 | R1378S | FKS2HS2 | 1–4 | 0.06–0.125 | 0.5–1 | 53 | |
| 1 | DelF659 + K335N | FKS2HS1 + FKS3 non-hotspot alteration | >4 | 1 | 2 | This study | |
| Pichia kudriavzevii (n = 11) | 1 | F655L | HS1 | 2 | 1 | 1 | 44 |
| 2 | S659F | HS1 | 4 | 2 | 0.5 | 38 | |
| 2 | S659S/P | HS1 | 0.5–1 | 0.125 | 0.06–0.125 | 38 | |
| Candida tropicalis (n = 5) | 2 | S645P | HS1 | 4 | 0.5 | 0.5 | 54 |
| 1 | F641L + I1368S | HS1 +HS2 | >4 | 2 | 2 | This study | |
| Kluyveromyces marxianus (n = 1) | 1 | F651F/S | HS1 | 0.5 | 0.5 | 1 | This study |