Table 4.
Associations of uEGF, sUmod, and measured glomerular filtration rate with graft IF % score
| Graft interstitial fibrosis percentage score | N | unstd. β-coeff (95% CI) | std. β-coeff | p value | R 2 |
|---|---|---|---|---|---|
| Univariable linear regression analysis | |||||
| Baseline | |||||
| uEGF/Cr | 90 | −0.381 (−0.597, −0.165) | −0.349 | 0.001 | 0.122 |
| sUmod | 90 | −0.091 (−0.159, −0.023) | −0.274 | 0.009 | 0.075 |
| mGFR | 90 | −0.233 (−0.397, −0.070) | −0.289 | 0.006 | 0.084 |
| End of study | |||||
| uEGF/Cr | 48 | −0.377 (−0.663, −0.092) | −0.365 | 0.011 | 0.133 |
| sUmod | 48 | −0.148 (−0.267, −0.029) | −0.347 | 0.016 | 0.120 |
| mGFR | 48 | −0.345 (−0.576, −0.114) | −0.405 | 0.004 | 0.164 |
|
| |||||
| Multivariable linear regression analysis | |||||
| Baseline | |||||
| uEGF/Cr | 90 | −0.407 (−0.673, −0.140) | −0.360 | 0.003 | 0.213* |
| sUmod | 90 | −0.112 (−0.191, −0.033) | −0.317 | 0.006 | 0.201* |
| mGFR | 90 | −0.215 (−0.405, −0.024) | −0.262 | 0.028 | 0.171* |
| End of study | |||||
| uEGF/Cr | 48 | −0.495 (−0.836, −0.155) | −0.439 | 0.006 | 0.436* |
| sUmod | 48 | −0.172 (−0.323, −0.020) | −0.360 | 0.028 | 0.382* |
| mGFR | 48 | −0.527 (−0.829, −0.224) | −0.586 | 0.001 | 0.485* |
The following variables were included in the multivariable model: recipient age and gender, marine n-3 PUFA intervention, urine albumin-to-creatinine ratio, systolic blood pressure, diastolic blood pressure, smoking status, diabetes mellitus (including post-transplant diabetes mellitus), donor status (living/deceased), DGF, and biopsy-proven acute rejection. Unstd., unstandardized; Std.; standardized, β-coeff., β-coefficient; CI, confidence intervals; mGFR, measured glomerular filtration rate.
*
R2 for the full multivariable linear regression model with all variables.