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. 2022 May 18;8(20):eabn7382. doi: 10.1126/sciadv.abn7382

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Fig. 2. — TEM of (A) RMSs, (B) RNSs, (C) NCs encapsulating Cas13a/crRNA, and (D) RNCOs. Scale bars, 500, 100, 100, and 100 nm, respectively. (E) DLS analysis of NCs, RNSs, and RNCOs. (F) Native PAGE (12%) analysis of the RCT process: (i) primer (P), (ii) linear ssDNA template (L_Apt), (iii) circular template, (iv) RCT product RMSs, (v) RMSs/C-Chol hybrid RNSs, and (vi) RNCOs. (G) Changes in zeta potential during the gradual formation of RNCOs. Data are means ± SD (n = 3). (H) UV-vis spectra of NCs, RNCs, and RNCOs. (i) CD spectra of NCs, RNCs, and RNCOs. a.u., arbitrary units.