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. 2021 Nov 20;24(5):768–777. doi: 10.1093/ntr/ntab206

Table 2.

Sample Weighted Geometric Mean Concentrations and 95% Confidence Intervals for Tobacco Users and Non-users Subdivided by Analyte and Category

Nicotine
(µg/g creat)
Cotinine
(µg/g creat)
Hydroxycotinine
(µg/g creat)
TNE2*
(µmol/g creat)
TNE3*
(µmol/g creat)
Daily Intermittent Daily Intermittent Daily Intermittent Daily Intermittent Daily Intermittent
Tobacco users
 All users
(n)
1281 [1218, 1347]
5610
177 [156, 201]
1900
2845 [2736, 2958]
5674
37.3 [31.1, 44.8]
3201
4877 [4655, 5110]
5674
65.0 [53.9, 78.4]
3201
43.7 [41.9, 45.5]
5674
0.58 [0.48,0.70]
3201
57.6 [55.6, 59.5]
5610
12.0 [10.9, 13.3]
1900
 Combustible (n) 1281 [1192, 1377]
3150
172 [146, 202]
1374
2776 [2629, 2932]
3180
31.5 [25.9, 38.3]
2385
4800 [4492, 5129]
3180
54.1 [44.4, 66.0]
2385
42.9 [40.5, 45.4]
3180
0.49 [0.40, 0.59]
2385
56.3 [53.9, 58.7]
3150
11.6 [10.4, 13.0]
1374
 Smokeless
(n)
1931 [1690, 2206]
349
294 [167, 517]
98
4323 [3781, 4943]
355
292 [129, 660]
121
7923 [6949, 9034]
355
517 [229, 1167]
121
68.7 [60.4, 78.2]
355
4.57 [2.04, 10.2]
121
92.6 [83.8, 102]
349
21.6 [14.4, 32.4]
98
 E-cigarette
(n)
785 [620, 993]
148
77.5 [33.6, 179]
43
1691 [1217, 2351]
152
8.16 [4.17, 16.0]
106
2934 [2124, 4052]
152
16.1 [8.61, 30.0]
106
26.3 [19.2, 36.1]
152
0.14 [0.07, 0.26]
106
37.0 [30.2, 45.3]
148
4.69 [2.34, 9.41]
43
 Polyuser
(n)
1230 [1151, 1314]
1963
195 [147, 259]
385
2894 [2729, 3070]
1987
78.7 [54.7, 113]
589
4798 [4489, 5129]
1987
143 [99.3, 207]
589
43.4 [40.9, 46.1]
1987
1.25 [0.87, 1.80]
589
57.3 [54.4, 60.4]
1963
13.5 [11.0, 16.7]
385
 Cigarette
(n)
1451 [1325, 1590]
2021
303 [243, 378]
684
3063 [2876, 3263]
2037
272 [193, 383]
837
5242 [4826, 5694]
2037
485 [341, 688]
837
46.9 [43.8, 50.3]
2037
4.34 [3.07, 6.13]
837
61.5 [58.2, 65.0]
2021
18.7 [16.0, 21.8]
684
Cotinine
(µg/g creat)
Hydroxycotinine
(µg/g creat)
TNE2*
(µmol/g creat)
All Non-SHS SHS All Non-SHS SHS All Non-SHS SHS
Non-users
 All non-users (n) 0.49 [0.42, 0.57]
2098
0.34 [0.30, 0.40]
1373
1.13 [0.86, 1.48]
725
0.81 [0.70, 0.94]
2098
0.57 [0.49, 0.65]
1373
1.95 [1.45, 2.62]
725
0.007 [0.006, 0.008]
2098
0.005 [0.004, 0.006]
1373
0.017 [0.013, 0.023]
725
 Never users
(n)
0.42 [0.36, 0.49]
1541
0.31 [0.27, 0.35]
1082
0.95 [0.70, 1.27]
459
0.69 [0.59, 0.81]
1541
0.50 [0.43, 0.58]
1082
1.62 [1.16, 2.27]
459
0.006 [0.005, 0.007]
1541
0.005 [0.004, 0.005]
1082
0.015 [0.011, 0.020]
459
 Former users (n) 1.36 [0.96, 1.92]
557
0.89 [0.57, 1.38]
291
2.64 [1.50, 4.65]
266
2.44 [1.70, 3.51]
557
1.58 [1.01, 2.48]
291
4.78 [2.69, 8.49]
266
0.021 [0.015, 0.030]
557
0.014 [0.009, 0.021]
291
0.042 [0.024, 0.074]
266

*TNE2 = (total cotinine/176.2151) + (total trans-3′-hydroxycotinine/192.2145) nmol/mL; TNE3 = (total nicotine/162.2316) + (total cotinine/176.2151) + (total trans-3′-hydroxycotinine/192.2145) nmol/mL.