Table 4.
Minor Metabolites and Total Nicotine Equivalents Among All Users and in Daily Users of Specific Tobacco Types
| Creatinine-adjusted weighted geometric mean concentrations and 95% confidence intervals for daily users | ||||
|---|---|---|---|---|
| Nicotine 1′-oxide (µg/g creat) |
Cotinine N-oxide (µg/g creat) |
Nornicotine (µg/g creat) |
TNE6* (µmol/g creat) |
|
| All users (n) | 244 [232, 256] (7510) | 236 [227, 247] (7510) | 46.3 [44.3, 48.3] (7501) | 42.2 [40.4, 44.0] (7501) |
| Combustible (n) | 389 [368, 410] (3150) | 344 [329, 360] (3150) | 69.9 [66.6, 73.3] (3143) | 61.6 [59.0, 64.2] (3143) |
| Smokeless (n) | 659 [585, 741] (349) | 516 [466, 573] (349) | 99.5 [88.4, 112] (348) | 101 [91.3, 111] (348) |
| E-cigarette (n) | 284 [231, 350] (148) | 209 [171, 255] (148) | 29.9 [24.6, 36.4] (148) | 40.4 [33.0, 49.4] (148) |
| Polyuser (n) | 382 [363, 401] (1963) | 347 [330, 364] (1963) | 65.5 [62.2, 68.9] (1963) | 62.4 [59.3, 65.6] (1963) |
| Cigarette (n) | 432 [405, 461] (2021) | 368 [348, 390](2021) | 76.1 [71.6, 80.9](2014) | 67.3 [63.8, 71.1](2014) |
| Unadjusted weighted geometric mean concentrations and 95% confidence intervals for daily users | ||||
| Nicotine 1′-oxide ng/mL |
Cotinine N-oxide ng/mL |
Nornicotine ng/mL |
TNE6* nmol/mL |
|
| All users (n) | 247 [234, 260] (7510) | 239 [228, 251] (7510) | 46.7 [44.7, 48.8] (7501) | 42.6 [40.8, 44.4] (7501) |
| Combustible (n) | 380 [357, 405] (3150) | 336 [318, 356] (3150) | 68.1 [64.7, 71.6] (3143) | 59.9 [57.3, 62.7] (3143) |
| Smokeless (n) | 662 [591, 742] (349) | 519 [467, 577] (349) | 99.8 [90.0, 111] (348) | 101 [93.0, 110] (348) |
| E-cigarette (n) | 249 [199, 313] (148) | 183 [149, 226] (148) | 26.3 [21.4, 32.2] (148) | 35.4 [28.9, 43.5] (148) |
| Polyuser (n) | 371 [349, 394] (1963) | 337 [317, 358] (1963) | 63.6 [59.4, 68.1] (1963) | 60.6 [57.3, 64,1] (1963) |
| Cigarette (n) | 406 [379, 435] (2021) | 346 [324, 369](2021) | 71.0 [67.0, 75.4](2014) | 62.9 [59.6, 66.3](2014) |
*TNE6 = (total nicotine/162.2316) + (total cotinine/176.2151) + (total trans-3′-hydroxycotinine/192.2145) + (total cotinine N-oxide/192.2145) + (nicotine 1′-oxide/178.231) + (nornicotine/148.2050) nmol/mL.