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. 2022 Jun 1;13(3):943–959. doi: 10.14336/AD.2021.1029

Figure 2.

Figure 2.

Semaglutide attenuated expression of CD16/32 in microglia after tMCAO. (A) Photomicrographs showed that CD16/32+/Iba-1+ cells (CD16/32 in green color; Iba-1 In red color) in the ipsilateral hemisphere of the perifocal area in sham mice, sham mice treated with semaglutide, tMCAO mice and semaglutide treated tMCAO mice. Scale bar=25 μm. Bar graphs showed the number of Iba-1+ cells and CD16/32+/Iba-1+ cells in the perifocal area of ipsilateral hemisphere in the semaglutide treated tMCAO mice and control mice. Data are mean±SEM, n=3 per group. *p<0.05, **p<0.01. (B) Bar graphs showed that the mRNA expression of IL-1α, TNFα and C1q in the perifocal area of ipsilateral hemisphere in the semaglutide treated tMCAO mice, the control mice and sham mice treated with semaglutide at day 3 after tMCAO. Data are mean±SEM, n=4 per group, *p<0.05.