Table 2:

Engraftment details for different humanized mice to study human NK cells

Strains	IR dose (cGy)	Number of hCD34+ cells	Time to reconstitution	Functional NK cell development
NSG	80	100k	≥12 weeks	No
NOG-IL2	250	50k	4 weeks	Yes *
NOG-IL15	Unknown	Unknown	Unknown	Unknown
NSG-IL15	80	100k	≥12 weeks	Unknown
NSG-IL7-IL15	150	2.5k – 26k	≥12 weeks	Yes
SRG	360	100k	≥12 weeks	No
SRG-15	360	100k	≥12 weeks	Yes *
NSG-SGM3	80	50k	7–8 weeks	Unknown
MISTRG	80 or none	10–50k	7–8 weeks	Yes *
BRGSF	300	200k	8–9 weeks	Yes

^*Studies with these three next-generation humanized mouse stains demonstrated NK cell-mediated killing of tumor cells in vivo (MHC class I-deficient tumor cells and/or ADCC).