Supplementary Table 7.
ORs and 95% CIs for Associations Between Metabolic Syndrome, Its Individual Components, and Gastrointestinal Cancer Risk, by Smoking Status
| Metabolic syndrome definition or component | OR (95% CI)a,b | HR (95% CI)a,b |
|---|---|---|
| N for study | 4238 cases + 21,190 controls | 366,016 |
| All participants | ||
| MetS (Harmonized) | 1.23 (1.15–1.32) | 1.21 (1.13–1.29) |
| MetS (NCEP-ATPIII) | 1.26 (1.17–1.35) | 1.24 (1.16–1.33) |
| MetS (IDF 2005) | 1.29 (1.20–1.39) | 1.27 (1.18–1.36) |
| Women | ||
| MetS (Harmonized) | 1.12 (0.99–1.27) | 1.12 (1.00–1.25) |
| MetS (NCEP-ATPIII) | 1.15 (1.02–1.29) | 1.14 (1.03–1.27) |
| MetS (IDF 2005) | 1.20 (1.05–1.38) | 1.21 (1.07–1.37) |
| Men | ||
| MetS (Harmonized) | 1.30 (1.19–1.42) | 1.26 (1.16–1.37) |
| MetS (NCEP-ATPIII) | 1.34 (1.22–1.46) | 1.31 (1.20–1.42) |
| MetS (IDF 2005) | 1.33 (1.22–1.46) | 1.29 (1.19–1.40) |
| Individual components | ||
| Obesity (IDF 2005 definition) | 1.26 (1.17–1.35) | 1.24 (1.16–1.32) |
| Obesity (NCEP-ATPIII definition) | 1.32 (1.23–1.42) | 1.29 (1.20–1.38) |
| HDL cholesterol | 1.14 (1.07–1.23) | 1.13 (1.06–1.21) |
| Abnormal glucose metabolism | 1.29 (1.19–1.39) | 1.25 (1.17–1.34) |
| Hypertension | 1.08 (1.01–1.16) | 1.09 (1.03–1.16) |
| High triglycerides | 1.08 (1.01–1.16) | 1.08 (1.01–1.15) |
Note: Boldface indicates statistical significance.
CI, Confidence interval; HR, hazard ratio; IDF 2005, International Diabetes Federation 2005; NCEP-ATPIII, National Cholesterol Education Program – Adult Treatment Panel III; OR, odds ratio.
Multivariable models were adjusted for total physical activity (<10, 10–20, 20–40, 40–60, >60 MET hour/week), height (cm, continuous), alcohol consumption frequency (never, special occasions only, 1–3 times/month, 1–2 times per week, 3–4 times/week, daily or almost daily, unknown/prefer not to answer), smoking intensity (never, previous, current <15 per day, current ≥15 per day, current unknown intensity, unknown/prefer not to answer), frequency of red and processed meat consumption (<2 per week, 2–2.99 times/week, 3–3.99 times/week, ≥4/week, unknown), educational level (CSE/GCSE/O-level, NVQ/HND/A-level/AS-level, other professional qualification, college/university degree, missing/prefer not to answer), regular aspirin or ibuprofen use (yes/no), ever use of hormone replacement therapy (yes/no) and, where appropriate, fasting time (hours, continuous).
ORs and HRs and are given for classified positive compared with negative for each component.