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. 2022 May 11;2022:2030818. doi: 10.1155/2022/2030818

Figure 5.

Figure 5

IFN-γ inhibited osteoclast differentiation and bone resorption in a dose-dependent manner. (a) Relative expression of osteoclast marker genes after 3 days of osteoclast differentiation. (b and c) Representative images of TRAP staining (b) and F-actin cytoskeleton staining (c) and quantitative analysis of osteoclast number per well (Oc. N/well). (d) Representative images of resorption pit assay and quantitative analysis of bone resorption area (the percentage of the resorbed pit area per total area). C: control (with M-CSF only); R: RANKL (with M-CSF and RANKL) (3 replicates, ∗P < 0.05).