Table 3.

Research Priorities in the Higher-Risk CAD Population Potentially Eligible for PCi

Research Priority/Question	Study design/Cohort
What is the prevalence of severe (and nonrevascularized) CAD?	Disease-based (as opposed to solely procedure-based) registries
What are the outcomes of PCI in higher-risk CAD patients (eg, nonsurgical patients), and are there specific operator/institution volumes that are required to achieve the best procedural outcomes?	Procedural registries
What are the costs associated with revascularization in higher-risk CAD patients?	Dedicated cost-effectiveness studies within procedure- and disease-based registries
What are the outcomes with PCI, surgical revascularization, and medical therapy among higher-risk patients with an indication for revascularization?	Disease-based registries with embedded procedural data Potential randomized trials
What is the variability in care patterns for patients meriting consideration of revascularization?	Disease-based registries with embedded procedural data
To what extent are contemporary interventionalists trained and skilled to perform complete revascularization across complex lesion subsets?	Procedure- and disease-based registries
To what extent can PCI achieve surgery-like outcomes in higher-risk CAD patients?	Randomized trials, possible comparative-effectiveness assessments

CAD indicates coronary artery disease; and PCI, percutaneous coronary intervention.