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. 2022 Apr 18;28(5):1006–1013. doi: 10.1038/s41591-022-01767-6

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Plots to the left of each arrow show the distributions of unadjusted published PRS (PRS_std-raw) by race for each of six diseases in up to 36,423 MGBB participants. Plots to the right of each arrow show these distributions after adjustment for population structure (PRS_std-adj), as described in the text. The red vertical line indicates the standardized PRS threshold corresponding to OR > 2 for each disease, based on the OR per standard deviation from the original publication.