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. 2022 Apr 14;28(5):939–945. doi: 10.1038/s41591-022-01754-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — B-F1RST prospectively evaluated atezolizumab monotherapy in the first-line treatment of patients with NSCLC. bTMB, blood-based tumor mutational burden; DOR, duration of response; ECOG PS, Eastern Cooperative Oncology Group performance status; INV, investigator; NSCLC, non-small cell lung cancer; OS, overall survival; PD, progressive disease; PD-L1, programmed death-ligand 1; PFS, progression-free survival; RECIST v1.1, Response Evaluation Criteria in Solid Tumors version 1.1. ^a Staging based on International Association for the Study of Lung Cancer Lung Cancer Staging Project 8th Edition of the TNM Classification for Lung Cancer²⁸. ^b Total enrolled, N = 153; however, 1 patient was never treated and was not included in the intention-to-treat population. ^c Tissue biopsy was optional.