Fig. 1. Predicted mean anti-spike IgG levels in participants with 10-week dosing interval by time from second vaccination according to vaccine type, age and prior infection status using GAMs adjusted for age and dosing interval.
a, 20-year-old. b, 40-year-old. c, 60-year-old. d, 80-year-old. Predicted levels are plotted on a log scale. Black dotted line indicates the threshold of IgG positivity (23 BAU ml−1); red solid line indicates the first vaccination; black solid line indicates the second vaccination. Line color indicates response predicted for ChAdOx1 and BNT162b2, with or without prior infection. See Extended Data Fig. 3 for a re-plotted version of the same estimates to allow comparison by age for each vaccine type and prior infection status. See Extended Data Fig. 4 for 8-week and 12-week dosing intervals. The 95% CIs are calculated by prediction ± 1.96 × standard error of the prediction.