Table 1.
Comparison of patient and tumor characteristics in women diagnosed with breast cancer by a history of cardiovascular diseases, stroke, hypertension, and diabetes in 1991–2015
| Number of cases (column %) by cardiovascular diseases (CVD), stroke, hypertension, and diabetes | ||||||||
| Patient and tumor characteristics | Cardiovascular diseases | Stroke | Hypertension | Diabetes | ||||
| Yes | No | Yes | No | Yes | No | Yes | No | |
| Median age (range) | 78 (65,103) | 74 (65,114) | 77 (65,114) | 74 (65,108) | 75 (65,114) | 72 (65,108) | 74 (65,105) | 74 (65,114) |
| Age (y) | ||||||||
| 65–69 | 3,164 (14.7) | 63,983 (28.4) | 3,593 (16.2) | 63,554 (28.3) | 37,206 (23.4) | 29,941 (34.1) | 37,206 (25.2) | 29,941 (27.8) |
| 70–74 | 4,153 (19.2) | 56,520 (25.1) | 4,764 (21.4) | 55,909 (24.9) | 38,409 (24.2) | 22,264 (25.4) | 38,409 (25.6) | 22,264 (24.3) |
| 75–79 | 4,906 (22.7) | 46,714 (20.8) | 5,052 (22.7) | 46,568 (20.8) | 35,097 (22.1) | 16,523 (18.8) | 35,097 (22.2) | 16,523 (20.5) |
| 80–84 | 4,471 (20.7) | 32,831 (14.6) | 4,646 (20.9) | 32,656 (14.6) | 26,764 (16.8) | 10,538 (12.0) | 26,764 (15.8) | 10,538 (14.9) |
| 85 or older | 4,901 (22.7) | 25,043 (11.1) | 4,177 (18.8) | 25,767 (11.5) | 21,495 (13.5) | 8,449 (9.6) | 21,495 (11.2) | 8,449 (12.4) |
| Race/ethnicity | ||||||||
| Whites | 18,213 (84.3) | 194,939 (86.6) | 18,857 (84.8) | 194,295 (86.6) | 134,309 (84.5) | 78,843 (89.9) | 45,135 (78.7) | 168,017 (88.7) |
| Blacks | 2,385 (11.0) | 16,823 (7.5) | 2,262 (10.2) | 16,946 (7.6) | 15,210 (9.6) | 3,998 (4.6) | 7,697 (13.4) | 11,511 (6.1) |
| Asians/Pacific Islanders | 536 (2.5) | 9,218 (4.1) | 834 (3.8) | 8,920 (4.0) | 6,806 (4.3) | 2,948 (3.4) | 3,295 (5.8) | 6,459 (3.4) |
| Others | 461 (2.1) | 4,111 (1.8) | 279 (1.3) | 4,293 (1.9) | 2,646 (1.7) | 1,926 (2.2) | 1,222 (2.1) | 3,350 (1.8) |
| Marital status | ||||||||
| Married | 6,694 (31.0) | 100,779 (44.8) | 6,694 (35.3) | 100,779 (44.4) | 65,891 (41.5) | 41,582 (47.4) | 22,456 (39.2) | 85,017 (44.9) |
| Unmarried | 13,786 (63.8) | 113,271 (50.3) | 13,786 (59.3) | 113,271 (50.7) | 85,165 (53.6) | 41,892 (47.8) | 31,829 (55.5) | 95,228 (50.3) |
| Unknown | 1,115 (5.2) | 11,041 (4.9) | 1,115 (5.4) | 11,041 (4.9) | 7,915 (5.0) | 4,241 (4.8) | 3,064 (5.3) | 9,092 (4.8) |
| AJCC tumor stage | ||||||||
| 0 and I | 9,463 (43.8) | 125,083 (55.6) | 11,439 (51.5) | 123,107 (54.9) | 87,153 (54.8) | 47,393 (54.0) | 29,688 (51.8) | 104,858 (55.4) |
| II | 6,893 (31.9) | 62,117 (27.6) | 6,181 (27.8) | 62,829 (28.0) | 44,620 (28.1) | 24,390 (27.8) | 16,861 (29.4) | 52,149 (27.5) |
| III | 1,979 (9.2) | 15,891 (7.1) | 1,878 (8.5) | 15,992 (7.1) | 11,875 (7.5) | 5,995 (6.8) | 4,831 (8.4) | 13,039 (6.9) |
| IV | 1,534 (7.1) | 10,561 (4.7) | 1,261 (5.7) | 10,834 (4.8) | 7,289 (4.6) | 4,806 (5.5) | 2,915 (5.1) | 9,180 (4.9) |
| Unknown/Missing | 1,726 (8.0) | 11,439 (5.1) | 1,473 (6.6) | 11,692 (5.2) | 8,034 (5.1) | 5,131 (5.9) | 3,054 (5.3) | 10,111 (5.3) |
| Tumor size (cm) | ||||||||
| < 1 | 3,227 (14.9) | 49,006 (21.8) | 4,148 (18.7) | 48,085 (21.4) | 33,410 (21.0) | 18,823 (21.5) | 10,883 (19.0) | 41,350 (21.8) |
| 1– < 2 | 6,275 (29.1) | 74,421 (33.1) | 6,763 (30.4) | 73,933 (32.9) | 51,396 (32.3) | 29,300 (33.4) | 17,880 (31.2) | 62,816 (33.2) |
| 2– < 3 | 4,150 (19.2) | 38,160 (17.0) | 3,990 (18.0) | 38,320 (17.1) | 27,791 (17.5) | 14,519 (16.6) | 10,407 (18.2) | 31,903 (16.9) |
| 3– < 4 | 2,176 (10.1) | 17,252 (7.7) | 2,003 (9.0) | 17,425 (7.8) | 12,854 (8.1) | 6,574 (7.5) | 5,105 (8.9) | 14,323 (7.6) |
| ≥4 | 3,577 (16.6) | 28,193 (12.5) | 3,283 (14.8) | 28,487 (12.7) | 20,744 (13.1) | 11,026 (12.6) | 8,227 (14.4) | 23,543 (12.4) |
| Missing | 2,190 (10.1) | 18,059 (8.0) | 2,045 (9.2) | 18,204 (8.1) | 12,776 (8.0) | 7,473 (8.5) | 4,847 (8.5) | 15,402 (8.1) |
| Tumor grade | ||||||||
| Well-differentiated | 3,878 (18.0) | 47,610 (21.2) | 4,526 (20.4) | 46,962 (20.9) | 33,212 (20.9) | 18,276 (20.8) | 10,982 (19.2) | 40,506 (21.4) |
| Moderately-differentiated | 8,113 (37.6) | 90,208 (40.1) | 8,843 (39.8) | 89,478 (39.9) | 64,295 (40.4) | 34,026 (38.8) | 23,183 (40.4) | 75,138 (39.7) |
| Poorly-differentiated | 6,101 (28.3) | 60,421 (26.8) | 6,066 (27.3) | 60,456 (26.9) | 43,132 (27.1) | 23,390 (26.7) | 16,453 (28.7) | 50,069 (26.4) |
| Unknown/Missing | 3,503 (16.2) | 26,852 (11.9) | 2,797 (12.6) | 27,558 (12.3) | 18,332 (11.5) | 12,023 (13.7) | 6,731 (11.7) | 23,624 (12.5) |
| Hormone receptor status | ||||||||
| Positive | 15,082 (69.8) | 169,925 (75.5) | 16,689 (75.1) | 168,318 (75.0) | 121,003 (76.1) | 64,004 (73.0) | 43,628 (76.1) | 141,379 (74.7) |
| Negative | 2,831 (13.1) | 28,875 (12.8) | 2,964 (13.3) | 28,742 (12.8) | 20,384 (12.8) | 11,322 (12.9) | 7,450 (13.0) | 24,256 (12.8) |
| Unknown | 3,682 (17.1) | 26,291 (11.7) | 2,579 (11.6) | 27,394 (12.2) | 175,84 (11.1) | 12,389 (14.1) | 6,271 (10.9) | 23,702 (12.5) |
| Chemotherapy (< 12 m) | ||||||||
| No | 18,502 (85.7) | 185,733 (82.5) | 19,326 (86.9) | 184,909 (82.4) | 132,573 (83.4) | 71,662 (81.7) | 47,593 (83.0) | 156,642 (82.7) |
| Yes | 3,093 (14.3) | 39,358 (17.5) | 2,906 (13.1) | 39,545 (17.6) | 263,98 (16.6) | 16,053 (18.3) | 9,756 (17.0) | 32,695 (17.3) |
| Radiotherapy (< 12 m) | ||||||||
| No | 13,947 (64.6) | 110,129 (48.9) | 13,065 (58.8) | 111,011 (49.5) | 81,702 (51.4) | 42,374 (48.3) | 30,679 (53.5) | 93,397 (49.3) |
| Yes | 7,648 (35.4) | 114,962 (51.1) | 9,167 (41.2) | 113,443 (50.5) | 77,269 (48.6) | 45,341 (51.7) | 26,670 (46.5) | 95,940 (50.7) |
| Comorbidity scores | ||||||||
| 0 | 12,494 (57.9) | 177,591 (78.9) | 13,470 (60.6) | 176,615 (78.7) | 114,840 (72.2) | 75,245 (85.8) | 38,965 (67.9) | 151,120 (79.8) |
| 1 | 6,466 (29.9) | 39,925 (17.7) | 6,166 (27.7) | 40,225 (17.9) | 35,388 (22.3) | 11,003 (12.5) | 13,612 (23.7) | 32,779 (17.3) |
| ≥2 | 2,635 (12.2) | 7,575 (3.4) | 2,596 (11.7) | 7,614 (3.4) | 8,743 (5.5) | 1,467 (1.7) | 4,772 (8.3) | 5,438 (2.9) |
| Year of Diagnosis | ||||||||
| 1992–1995 | 2,111 (9.8) | 15,941 (7.1) | 866 (3.9) | 17,186 (7.7) | 7,544 (4.8) | 10,508 (12.0) | 2,483 (4.3) | 15,569 (8.2) |
| 1996–1999 | 2,037 (9.4) | 16,618 (7.4) | 906 (4.1) | 17,749 (7.9) | 8,508 (5.4) | 10,147 (11.6) | 2,631 (4.6) | 16,024 (8.5) |
| 2000–2003 | 4,619 (21.4) | 34,229 (15.2) | 1,865 (8.4) | 36,983 (16.5) | 21,049 (13.2) | 17,799 (20.3) | 6,394 (11.2) | 32,454 (17.1) |
| 2004–2007 | 4,792 (22.2) | 43,799 (19.5) | 3,023 (13.6) | 45,568 (20.3) | 32,133 (20.2) | 16,458 (18.8) | 11,003 (19.2) | 37,588 (19.9) |
| 2008–2011 | 4,066 (18.8) | 56,726 (25.2) | 8,179 (36.8) | 52,613 (23.4) | 45,367 (28.5) | 15,425 (17.6) | 17,079 (29.8) | 43,713 (23.1) |
| 2012–2017 | 3,970 (18.4) | 57,778 (25.7) | 7,393 (33.3) | 54,355 (24.2) | 44,370 (27.9) | 17,378 (19.8) | 17,759 (31.0) | 43,989 (23.2) |
| SEER Areas | ||||||||
| Connecticut | 1,642 (7.6) | 16,005 (7.1) | 1,354 (6.1) | 16,293 (7.3) | 11,102 (7.0) | 6,545 (7.5) | 3,620 (6.3) | 14,027 (7.4) |
| Detroit | 2,316 (10.7) | 16,175 (7.2) | 1,858 (8.4) | 16,633 (7.4) | 12,139 (7.6) | 6,352 (7.2) | 4,918 (8.6) | 13,573 (7.2) |
| Hawaii | 195 (0.9) | 3,184 (1.4) | 262 (1.2) | 3,117 (1.4) | 2,214 (1.4) | 1,165 (1.3) | 859 (1.5) | 2,520 (1.3) |
| Iowa | 1,527 (7.1) | 15,972 (7.1) | 1,147 (5.2) | 16,352 (7.3) | 10,245 (6.4) | 7,254 (8.3) | 3,325 (5.8) | 14,174 (7.5) |
| New Mexico | 472 (2.2) | 5,582 (2.5) | 390 (1.8) | 5,664 (2.5) | 3,310 (2.1) | 2,744 (3.1) | 1,089 (1.9) | 4,965 (2.6) |
| Seattle | 1,153 (5.3) | 14,892 (6.6) | 1,046 (4.7) | 14,999 (6.7) | 8,531 (5.4) | 7,514 (8.6) | 2,669 (4.7) | 13,376 (7.1) |
| Utah | 571 (2.6) | 6,089 (2.7) | 337 (1.5) | 6,323 (2.8) | 3,568 (2.2) | 3,092 (3.5) | 1,262 (2.2) | 5,398 (2.9) |
| Georgia | 1,592 (7.4) | 20,120 (8.9) | 2,205 (9.9) | 19,507 (8.7) | 15,512 (9.8) | 6,200 (7.1) | 5,615 (9.8) | 16,097 (8.5) |
| Kentucky | 1,525 (7.1) | 13,377 (5.9) | 1,425 (6.4) | 13,477 (6.0) | 10,955 (6.9) | 3,947 (4.5) | 3,967 (6.9) | 10,935 (5.8) |
| Louisiana | 1,352 (6.3) | 11,803 (5.2) | 1,634 (7.4) | 11,521 (5.1) | 9,860 (6.2) | 3,295 (3.8) | 3,715 (6.5) | 9,440 (5.0) |
| New Jersey | 3,116 (14.4) | 29,171 (13) | 3,793 (17.1) | 28,494 (12.7) | 23,831 (15.0) | 8,456 (9.6) | 9,504 (16.6) | 22,783 (12.0) |
| California | 6,134 (28.4) | 72,721 (32.3) | 6,781 (30.5) | 72,074 (32.1) | 47,704 (30.0) | 31,151 (35.5) | 16,806 (29.3) | 62,049 (32.8) |
| Total | 21,595 (100.0) | 225,091 (100.0) | 22,232 (100.0) | 224,454 (100.0) | 158,971 (100.0) | 87,715 (100.0) | 57,349 (100.0) | 189,337 (100.0) |