Table 2.

Cumulative incidence of ADRD by a history of CVD, stroke, hypertension, and diabetes in women with breast cancer with up to 26 years of follow-up from 1991 to 2016

	Cumulative incidence (row %) of ADRD
Characteristics	AD	Vascular	Lewy	FTD	MCI	Others	Total
Cardiovascular disease
No	11.59	4.47	0.79	0.24	2.43	29.24	31.32
Yes	13.60	6.23	0.66	0.13	1.83	38.07	40.75
Stroke
No	11.67	4.35	0.77	0.23	2.30	29.28	31.34
Yes	12.83	7.38	0.87	0.20	3.18	37.41	40.24
Hypertension
No	12.25	4.36	0.81	0.24	2.22	28.43	30.47
Yes	11.50	4.76	0.76	0.22	2.46	30.88	33.06
Diabetes
No	12.10	4.53	0.81	0.23	2.38	29.68	31.77
Yes	10.69	4.90	0.76	0.21	2.37	31.11	33.38
Age (years)
65–69	5.02	2.14	0.47	0.20	1.68	16.18	17.67
70–74	9.42	3.74	0.79	0.24	2.38	25.04	26.97
75–79	14.32	5.66	0.99	0.28	2.95	34.88	37.21
80–84	18.63	7.13	1.09	0.26	2.96	42.83	45.50
85 or older	18.73	7.04	0.69	0.15	2.22	46.74	49.69
Race/ethnicity
Whites	11.79	4.53	0.79	0.24	2.45	30.06	32.17
Blacks	12.54	5.86	0.65	0.16	1.94	31.39	33.65
Asians/Pacific Islanders	8.02	3.35	0.56	0.15	1.71	22.96	25.14
Others	15.66	6.36	0.98	0.22	2.08	37.01	39.30
Marital status
Married	9.76	3.59	0.77	0.22	2.35	24.94	26.87
Unmarried	13.48	5.51	0.78	0.23	2.41	34.33	36.64
Unknown	11.75	4.47	0.78	0.25	2.20	29.67	31.75
AJCC tumor stage
0 or I	11.87	4.59	0.84	0.25	2.75	29.19	31.34
II	12.85	5.29	0.80	0.24	2.29	32.48	34.68
III	9.35	3.46	0.60	0.15	1.55	28.20	30.11
IV	4.32	1.61	0.19	0.04	0.65	19.76	21.10
Unknown/Missing	15.21	5.77	0.85	0.22	1.78	37.39	39.91
Tumor size (cm)
< 1	11.26	4.39	0.86	0.25	2.84	27.87	30.06
1– < 2	12.61	4.90	0.83	0.26	2.68	31.03	33.16
2– < 3	12.32	5.13	0.80	0.22	2.22	31.49	33.73
3– < 4	12.11	4.48	0.73	0.18	1.81	32.12	34.13
≥4	10.08	4.02	0.58	0.17	1.76	28.43	30.44
Missing	10.90	4.09	0.66	0.18	1.83	28.86	30.89
Tumor grade
Well-differentiated	12.14	4.69	0.91	0.26	2.88	30.15	32.22
Moderately-differentiated	11.71	4.56	0.78	0.24	2.43	29.58	31.71
Poorly-differentiated	10.69	4.25	0.69	0.20	2.11	28.78	30.91
Unknown/Missing	13.68	5.48	0.72	0.18	1.91	33.86	36.12
Hormone receptor status
Positive	11.42	4.49	0.78	0.24	2.47	29.25	31.36
Negative	10.12	3.91	0.66	0.19	2.13	27.32	29.28
Unknown	15.69	6.15	0.86	0.22	2.05	37.57	40.01
Chemotherapy
No	12.48	4.91	0.82	0.23	2.43	31.00	33.20
Yes	8.36	3.25	0.55	0.21	2.13	25.25	27.05
Radiotherapy
No	13.42	5.28	0.82	0.22	2.17	33.76	36.05
Yes	10.10	3.96	0.74	0.24	2.59	26.22	28.18
Comorbidity scores
0	12.29	4.73	0.81	0.24	2.37	29.94	32.04
1	10.12	4.15	0.67	0.20	2.47	29.75	31.90
≥2	9.55	4.79	0.60	0.19	2.02	32.61	35.10
SEER Areas
Connecticut	14.83	9.55	0.78	0.32	2.56	35.63	38.18
Detroit	17.78	7.55	0.86	0.24	2.04	38.91	41.16
Hawaii	12.70	7.04	0.56	0.12	2.93	31.58	34.18
Iowa	11.97	3.88	0.73	0.22	1.83	32.57	34.13
New Mexico	11.12	3.85	0.89	0.21	1.95	32.11	33.63
Seattle	9.63	4.13	0.50	0.17	1.65	24.49	26.63
Utah	9.61	3.62	0.60	0.12	1.65	27.82	29.65
Georgia	10.20	3.28	0.71	0.20	1.88	24.86	26.85
Kentucky	12.18	3.76	0.87	0.24	1.55	32.20	33.47
Louisiana	10.64	3.22	0.69	0.17	1.77	26.55	28.53
New Jersey	11.75	4.76	0.81	0.27	2.60	28.60	31.04
California	10.81	3.84	0.84	0.23	3.05	29.35	31.62
Total	11.77	4.62	0.78	0.23	2.38	30.01	32.14

ADRD, Alzheimer’s disease and related dementias; AD, Alzheimer’s disease; Vascular, vascular dementia; Lewy, dementia with Lewy bodies; FTD, frontotemporal degeneration and dementias; MCI, mild cognitive impairment; Others, other dementias; Total, any of above ADRD).