Table 3.
Incidence density of ADRD by a history of CVD, stroke, hypertension, and diabetes in women with breast cancer with up to 26 years of follow-up from 1991 to 2016
| Incidence density of ADRD (number of ADRD cases per 1,000 person-years) | |||||||
| Characteristics | AD | Vascular | Lewy | FTD | MCI | Others | Total |
| Cardiovascular disease | |||||||
| No | 18.13 | 6.98 | 1.23 | 0.37 | 3.80 | 45.72 | 48.97 |
| Yes | 30.83 | 14.12 | 1.50 | 0.30 | 4.16 | 86.33 | 92.41 |
| Stroke | |||||||
| No | 18.19 | 6.78 | 1.20 | 0.36 | 3.58 | 45.66 | 48.87 |
| Yes | 29.88 | 17.18 | 2.03 | 0.47 | 7.41 | 87.13 | 93.74 |
| Hypertension | |||||||
| No | 17.07 | 6.08 | 1.13 | 0.33 | 3.09 | 39.62 | 42.46 |
| Yes | 20.20 | 8.36 | 1.33 | 0.39 | 4.33 | 54.23 | 58.06 |
| Diabetes | |||||||
| No | 18.38 | 6.89 | 1.21 | 0.36 | 3.62 | 45.09 | 48.26 |
| Yes | 21.25 | 9.74 | 1.43 | 0.41 | 4.70 | 61.84 | 66.34 |
| Age (years) | |||||||
| 65–69 | 6.93 | 2.96 | 0.65 | 0.27 | 2.32 | 22.35 | 24.41 |
| 70–74 | 13.57 | 5.38 | 1.13 | 0.34 | 3.42 | 36.05 | 38.83 |
| 75–79 | 22.63 | 8.94 | 1.56 | 0.44 | 4.66 | 55.12 | 58.8 |
| 80–84 | 36.05 | 13.81 | 2.11 | 0.51 | 5.73 | 82.90 | 88.08 |
| 85 or older | 52.01 | 19.55 | 1.92 | 0.42 | 6.17 | 129.80 | 137.99 |
| Race/ethnicity | |||||||
| Whites | 18.74 | 7.2 | 1.26 | 0.38 | 3.90 | 47.78 | 51.14 |
| Blacks | 24.20 | 11.3 | 1.26 | 0.30 | 3.74 | 60.57 | 64.94 |
| Asians/Pacific Islanders | 13.35 | 5.58 | 0.94 | 0.26 | 2.85 | 38.25 | 41.87 |
| Others | 20.04 | 8.15 | 1.26 | 0.28 | 2.66 | 47.36 | 50.3 |
| Marital status | |||||||
| Married | 14.09 | 5.18 | 1.12 | 0.32 | 3.40 | 36.02 | 38.81 |
| Unmarried | 23.59 | 9.64 | 1.37 | 0.41 | 4.22 | 60.10 | 64.14 |
| Unknown | 22.06 | 8.39 | 1.47 | 0.46 | 4.12 | 55.71 | 59.62 |
| AJCC tumor stage | |||||||
| 0 and I | 17.17 | 6.63 | 1.21 | 0.36 | 3.97 | 42.21 | 45.34 |
| II | 20.50 | 8.45 | 1.27 | 0.38 | 3.65 | 51.81 | 55.32 |
| III | 21.07 | 7.8 | 1.35 | 0.34 | 3.50 | 63.60 | 67.89 |
| IV | 19.96 | 7.44 | 0.88 | 0.19 | 3.01 | 91.21 | 97.39 |
| Unknown/Missing | 30.13 | 11.43 | 1.68 | 0.44 | 3.52 | 74.06 | 79.04 |
| Tumor size (cm) | |||||||
| < 1 | 15.90 | 6.2 | 1.21 | 0.36 | 4.01 | 39.36 | 42.46 |
| 1– < 2 | 18.10 | 7.03 | 1.19 | 0.37 | 3.85 | 44.54 | 47.6 |
| 2– < 3 | 20.00 | 8.33 | 1.30 | 0.36 | 3.60 | 51.11 | 54.75 |
| 3– < 4 | 23.19 | 8.58 | 1.39 | 0.34 | 3.46 | 61.51 | 65.35 |
| ≥4 | 22.72 | 9.06 | 1.31 | 0.39 | 3.96 | 64.04 | 68.57 |
| Missing | 22.18 | 8.32 | 1.35 | 0.36 | 3.72 | 58.72 | 62.86 |
| Tumor grade | |||||||
| Well-differentiated | 18.10 | 7 | 1.35 | 0.38 | 4.30 | 44.94 | 48.03 |
| Moderately-differentiated | 18.46 | 7.2 | 1.23 | 0.38 | 3.84 | 46.64 | 49.99 |
| Poorly-differentiated | 18.55 | 7.38 | 1.20 | 0.35 | 3.66 | 49.95 | 53.64 |
| Unknown/Missing | 22.79 | 9.12 | 1.21 | 0.31 | 3.19 | 56.38 | 60.14 |
| Hormone receptor status | |||||||
| Positive | 18.18 | 7.16 | 1.25 | 0.38 | 3.94 | 46.57 | 49.93 |
| Negative | 17.98 | 6.95 | 1.18 | 0.34 | 3.78 | 48.51 | 51.99 |
| Unknown | 24.20 | 9.48 | 1.33 | 0.34 | 3.15 | 57.95 | 61.71 |
| Chemotherapy | |||||||
| No | 20.35 | 8 | 1.34 | 0.38 | 3.96 | 50.56 | 54.15 |
| Yes | 12.57 | 4.88 | 0.83 | 0.32 | 3.20 | 37.96 | 40.65 |
| Radiotherapy | |||||||
| No | 24.23 | 9.53 | 1.47 | 0.39 | 3.91 | 60.96 | 65.1 |
| Yes | 14.61 | 5.72 | 1.07 | 0.35 | 3.74 | 37.93 | 40.77 |
| Comorbidity scores | |||||||
| 0 | 18.53 | 7.13 | 1.23 | 0.36 | 3.58 | 45.13 | 48.3 |
| 1 | 19.94 | 8.17 | 1.32 | 0.40 | 4.88 | 58.64 | 62.88 |
| ≥2 | 25.35 | 12.72 | 1.59 | 0.49 | 5.36 | 86.57 | 93.2 |
| SEER Areas | |||||||
| Connecticut | 21.80 | 14.04 | 1.14 | 0.47 | 3.76 | 52.37 | 56.12 |
| Detroit | 26.06 | 11.07 | 1.26 | 0.35 | 2.99 | 57.03 | 60.33 |
| Hawaii | 17.50 | 9.71 | 0.78 | 0.16 | 4.04 | 43.53 | 47.12 |
| Iowa | 16.72 | 5.42 | 1.02 | 0.31 | 2.56 | 45.51 | 47.7 |
| New Mexico | 16.58 | 5.74 | 1.33 | 0.32 | 2.91 | 47.89 | 50.15 |
| Seattle | 14.07 | 6.04 | 0.73 | 0.25 | 2.41 | 35.78 | 38.91 |
| Utah | 14.26 | 5.37 | 0.89 | 0.18 | 2.45 | 41.29 | 44.01 |
| Georgia | 19.08 | 6.13 | 1.33 | 0.38 | 3.52 | 46.49 | 50.21 |
| Kentucky | 21.57 | 6.67 | 1.53 | 0.43 | 2.74 | 57.01 | 59.26 |
| Louisiana | 19.58 | 5.93 | 1.27 | 0.32 | 3.26 | 48.84 | 52.49 |
| New Jersey | 20.80 | 8.43 | 1.43 | 0.48 | 4.61 | 50.60 | 54.93 |
| California | 17.42 | 6.18 | 1.36 | 0.37 | 4.92 | 47.30 | 50.97 |
| Total | 18.92 | 7.43 | 1.25 | 0.37 | 3.82 | 48.24 | 51.66 |
ADRD, Alzheimer’s disease and related dementias; AD, Alzheimer’s disease; Vascular, vascular dementia; Lewy, dementia with Lewy bodies; FTD, frontotemporal degeneration and dementias; MCI, mild cognitive impairment; Others, other dementias; Total, any of above ADRD.