Table 2.
Clinical variables contributing to optimal medial therapy administration.
| Variable | Beta-blockers | RAS-inhibitors | MRAs | |||
|---|---|---|---|---|---|---|
| OR [95% CI] | p value | OR [95% CI] | p value | OR [95% CI] | p value | |
| Male | 0.57 [0.37–0.90] | 0.016 | 0.84 [0.60–1.16] | 0.287 | 0.83 [0.62–1.11] | 0.209 |
| Age (per 1 year increase) | 0.95 [0.93–0.97] | < 0.001 | 0.99 [0.98–1.00] | 0.164 | 0.99 [0.98–1.01] | 0.234 |
| Prior HF hospitalization | 1.06 [0.69–1.62] | 0.805 | 1.12 [0.82–1.54] | 0.473 | 1.61 [1.22–2.13] | < 0.001 |
| Systolic blood pressure (per 1 mmHg increase) | 1.00 [1.00–1.01] | 0.512 | 1.00 [1.00–1.01] | 0.202 | 0.99 [0.99–1.00] | 0.310 |
| Heart rate (per 1 beat/min increase) | 1.01 [1.00–1.01] | 0.171 | 1.00 [0.99–1.00] | 0.149 | 1.00 [0.99–1.01] | 0.469 |
| eGFR (per 1 mL/min/1.72 m2 increase) | 1.00 [0.99–1.01] | 0.912 | 1.02 [1.02–1.03] | < 0.001 | 1.01 [1.00–1.02] | 0.004 |
| Potassium level (per 1 mEq/L increase) | 1.32 [0.88–1.98] | 0.188 | 1.15 [0.86–1.54] | 0.361 | 0.95 [0.73–1.24] | 0.721 |
| Total cholesterol level (per 1 mg/dL) | 1.00 [0.99–1.00] | 0.239 | 1.00 [1.00–1.01] | 0.544 | 1.00 [1.00–1.00] | 0.034 |
| Atrial fibrillation | 0.97 [0.65–1.46] | 0.882 | 1.20 [0.88–1.64] | 0.247 | 0.92 [0.70–1.20] | 0.528 |
| Ischemic cardiomyopathy | 1.17 [0.77–1.77] | 0.456 | 1.23 [0.90–1.68] | 0.200 | 1.15 [0.87–1.51] | 0.339 |
| Diabetes mellitus | 1.02 [0.67–1.54] | 0.946 | 0.78 [0.58–1.06] | 0.782 | 1.20 [0.92–1.57] | 0.178 |
| Hypertension | 1.43 [0.94–2.16] | 0.094 | 1.36 [0.99–1.88] | 0.060 | 0.99 [0.75–1.31] | 0.948 |
| COPD | 0.61 [0.28–1.29] | 0.228 | 1.41 [0.66–2.97] | 0.374 | 0.67 [0.35–1.28] | 0.228 |
| LVEF (per 1% increase) | 0.98 [0.95–1.01] | 0.103 | 1.00 [0.98–1.02] | 0.855 | 0.97 [0.95–0.99] | 0.002 |
| GNRI (continuous variable) | 1.02 [1.00–1.04] | 0.043 | 1.03 [1.02–1.05] | < 0.001 | 1.00 [0.99–1.01] | 0.597 |
RAS-I renin-angiotensin system inhibitor, MRA mineralocorticoid receptor antagonist, HF heart failure, eGFR estimated glomerular filtration rate, COPD chronic obstructive pulmonary disease, LVEF left ventricular ejection fraction, GNRI geriatric nutritional risk index.