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. 2022 May 18;7:54. doi: 10.1038/s41541-022-00476-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Body temperatures in experiment 1 (a) and experiment 2 (b) were recorded every 15 min using an AniPill telemetric device in the abdominal cavity. Averages and SEM are presented for each group. Area under the curve (AUC) measurements were performed at the indicated days post inoculation (DPI) to assess statistically significant differences between groups of experiment 1 (c) and, groups of experiment 2 (d). Data are presented as violin plots with medians (dashed line) and were analyzed by (c) unpaired t-test or (d) one-way ANOVA using Dunnett’s multiple comparisons test and comparing the individual vaccine groups to the corresponding wild-type virus groups (GraphPad Prism 9.0). Statistical significance (p value ≤ 0.05) is indicated with an asterisk (*).