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. 2022 Apr 25;79:104016. doi: 10.1016/j.ebiom.2022.104016

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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PDAC ILC2s are derived from the circulation and correlate with CCL2.

(a) Number of lymphocytes in non-tumor tissues with (n = 7) or without pancreatitis (n = 8). (b) Representative flow plot of CD103 in lymphocytes in the indicated tissues. (c) Percentage of CD103⁺ in lymphocytes from spleen (n = 4), PBMC (n = 4), intra-tumor (n = 4), peri-tumor (n = 4), and non-tumor tissues (n = 4) as well as pancreas with pancreatitis (n = 3). (d) Correlation between the indicated chemokine and HIF1A in the TCGA (PDAC) database. (e) FPKM of Ccr2, Ccr4, and Ccr5 in control and 24h hypoxia mouse ILC2 groups. (f) Expression of CCR2, CCR3, CCR4 CCR5, and CCR6 in CD103⁻ ILC2 (CyTOF data) (n = 6). (g) Representative flow plot and (h) statistical analysis of CCR2 in human tumor-derived ILC2s and Lin⁻CD127⁻ (n = 4). (i) Mouse ILC2s migrate in response to CCL2 under hypoxia condition (n = 5). Data are expressed as means ± SD and compared using the unpaired t test (*,P < 0.05; **, P < 0.01; ***, P < 0.001).